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. 2021 Mar 5;14(3):691–702. doi: 10.1038/s41385-021-00380-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Representative super-resolution STED images of Ple^fl/fl and Ple^ΔIEC distal colon sections immunolabeled for pan-keratin (pan-K; green) with nuclei stained with Hoechst (blue). Scale bar, 10 μm. Boxed areas show ×1.3 images. B, C Relative mRNA (B) and protein (C) levels of K8, 18, and 19 in Ple^fl/fl and Ple^ΔIEC distal colon, n = 3–5. Data are presented as mean ± SEM, P > 0.05 by unpaired Student t test. D Representative immunofluorescence images of WT and KO Caco-2 cell monolayer cultures immunolabeled for pan-K (green) and desmoplakin (Dsp; red). Nuclei were stained with Hoechst (blue). Arrows, straight K8 filaments anchored to Dsp-positive desmosomes; arrowheads, tangled K8 filaments. Scale bar, 20 μm. Boxed areas show ×2.5 images.