Table 1.

Baseline clinical and tumor characteristics

Patient	Age (years)	GCT type	Years since initial diagnosis	ECOG PS	FIGO stage1	Metastatic sites2	PD-L1 H-score	TIL infiltration
1	54	Adult	16	1	IC1	A, P	0	3
2	38	Adult	12	0	I	A, L, P	0	1
3	73	Adult	26	1	IC	H, I, P, S	N/A3	N/A3
4	23	Juvenile	2	1	IIA	A, P	0	1
5	70	Adult	8	1	IIB	H, P	0	2

GCT = granulosa cell tumor, ECOG PS = Eastern Cooperative Oncology Group Performance Status, FIGO = International Federation of Gynecology and Obstetrics, PD-L1 = programmed cell death ligand-1, TIL = tumor-infiltrating lymphocyte, I = intestinal metastases, A = adenopathy, P = peritoneal metastases, L = lung metastases, H = hepatic metastases, S = splenic metastases, N/A = not applicable.

Percentage and intensity of PD-L1 membrane staining on a scale from 0 to 300, with ≥ 42.5 defined as the threshold for positivity of PD-L1. TIL = intensity of TILs within tumor nests on a scale of 0 to 3; 0 = absence of TILs, 1 = low number of TILs, 2 = moderate number of TILs, 3 = high number of TILs.

¹FIGO 2015 staging.

²Sites of metastatic disease prior to treatment.

³Patient 3 had no tumor present in the tissue specimen for PD-L1 and TIL evaluation.