Table 1.

Clinicopathologic features of EH characterized by GATA6-FOXO1 fusions

EH#	Age/ Sex	Site/Size/ Procedure/FU	Microscopic Features	IHC positive
1	42/F	R leg, subcutis 1 cm Resection, negative margins	Biphasic, vasoformation and solid growth Intravascular Abundant inflammation (lympho-plasma cells), Extravasated red blood cells 1 MF/10 HPF, mild atypia	CD31, CD34, ERG
2	32/M	Cheek, skin 1.2 cm; Resection, negative margins; NED 6 months	Biphasic, vasoformation and solid growth Scant to no inflammation Limited extravasation 2 MF/10 HPFs, mild atypia	CD31, ERG
3	33/F	Dura 3 x 2.5 x 1 cm aggregate; Craniotomy, intralesional resection; NED 36 months	Biphasic, vasoformation and solid growth Epithelioid, ovoid to spindling (short fascicles) Abundant extravasated blood Scant acute inflammation 2 MF/10 HPFs, moderate atypia	CD31, CD34
4	42/F	H&N, nasopharyngeal 2.4 cm Biopsy only AWD 48 months	Scant vasoformation Epithelioid, solid, nodular Scant to no inflammation Moderate extravasated blood, 1 MF/10 HPFs, mild atypia	CD31, ERG
5	15/M	Left upper back, Skin 0.5 x 0.3 cm Incomplete resection	Biphasic, vasoformation and solid growth Moderate extravasated blood Scattered eosinophils 2 MF/10 HPF, moderate nuclear atypia	CD31, ERG

FU, follow-up; NED, no evidence of disease; AWD, alive with disease.