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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Kidney Int. 2021 Jan 4;99(5):1102–1117. doi: 10.1016/j.kint.2020.12.022

Figure 3: Glomerular Myo9A expression in glomerular disease mouse models.

Figure 3:

A) developmental nephrotic syndrome induced by VEGF-A overexpression:27 IF shows Myo9A (red) in glomeruli from normal, uninduced 2 week old mice and clearly decreased Myo9A expression in glomeruli from nephrotic mice overexpressing VEGF-A, while podocin (green) is unchanged. B) Streptozotocin-induced diabetes with or without VEGF-A overexpression:26 IF detects Myo9A (green) in glomeruli from uninduced diabetic kidneys (DM control) and markedly decreased immunoreactive Myo9A in glomeruli from diabetic mice overexpressing VEGF-A that develop diabetic glomerulosclerosis (advanced DN), Dapi (blue) shows nuclei from both sections with outlined glomeruli (hatched white line). Scale bars= 50μm.