Table 1.
Targeting TrkB in Seizure Disorders
| Citation (PMID) | Date | Model | Method | Age | Results |
|---|---|---|---|---|---|
| Isackson et al. (2054188) | 1991 | DG focal lesion in male rats | Behavioral seizure scoring | Adult | BDNF mRNA expression is increased after limbic seizures |
| Kokaia et al. (7649227) | 1995 | Electrical kindling in male mice | Behavioral seizure scoring | Adult | The development of electrical kindling is suppressed in BDNF+/− mice |
| Binder et al. (9952416) | 1999 | Electrical kindling in male rats | Behavioral seizure scoring | Adult | Chronic intraventricular infusion of TrkB receptor bodies inhibited the development of electrical kindling |
| Croll et al. (10501474) | 1999 | Intraperitoneal KA injection in mice | Behavioral seizure scoring | Adult | BDNF overexpression increased KA seizure severity |
| Lahteinen et al. (11886452) | 2002 | Intraperitoneal KA injection in male mice | Video-EEG monitoring | Adult | Transgenic mice that overexpress truncated TrkB had significantly less spontaneous recurrent seizures and interictal spikes after KA induced epilepsy |
| Scharfman et al. (11922662) | 2002 | Chronic BDNF intrahippocamp al infusion in male rats | Behavioral seizure scoring and acute scalp recordings | Adult | Chronic intrahippocampal infusion of BDNF induced spontaneous seizures and decreased latency to pilocarpine induced status epilepticus |
| He et al. (15233915) | 2004 | Electrical kindling in mice | Behavioral seizure scoring | Adult | Conditional deletion of TrkB prevented the development of electrical kindling |
| He et al. (20445044) | 2010 | Electrical kindling in TrkBPLC/PLC mice | Behavioral seizure scoring | Adult | Genetic uncoupling of TrkB (Y816F) from PLCƴ/1 inhibited the development of electrical kindling |
| Liu et al. (23790754) | 2013 | Right amygdala KA infusion in adult TrkBF616A mice | Video-EEG monitoring | Adult | Chemical-genetic inhibition of TrkB (two weeks) in combination with diazepam (40 minutes) and lorazepam (1 hour) prevented spontaneous recurrent seizures after KA induced SE |
| Gu et al. (26481038) | 2015 | Electrical kindling in mice | Video-EEG monitoring | Adult | Peptide that prevents the coupling of TrkB pY816 to PLCγ1 prevents kindling |
| Kang et al. (26452067) | 2015 | Unilateral carotid ligation in P7 CD-1 mice | Video-EEG monitoring | Neonatal | Acute TrkB-inhibition with ANA-12 prevented phenobarbital resistant neonatal seizures in P7 CD- 1 pups |
| Carter et al. (30097625) | 2018 | Unilateral carotid ligation in P7 and P10 CD-1 mice | Video-EEG monitoring | Neonatal | Acute TrkB-inhibition with ANA-12 prevented phenobarbital resistant P7 neonatal seizures in a dose dependent manner |
| Gu et al. (29408225) | 2018 | Partial neocortical isolation model in rats | Video-EEG monitoring | Adult | Chronic administration of the TrkB agonist PTX BD4–3 after UC decreased PTZ induced electrographic and behavioral ictal events |
| Riffault et al. (27913431) | 2018 | PTZ injection in CR-proBDNF mice | Behavioral seizure scoring | Adult | Cleavage resistant proBDNF increased the severity of PTZ induced seizures and the frequency of seizures in the pilocarpine model of temporal lobe epilepsy |
| Krishnamurthy et al. (31525273) | 2019 | Electrical kindling in mice | Video-EEG monitoring | Adult | Acute chemical genetic TrkB inhibition prevented the development of electrical kindling |
| Kang et al. (31864171) | 2020 | Unilateral carotid ligation in P7 CD-1 pups | Video-EEG monitoring | Neonatal and Adult | Acute TrkB inhibition with ANA-12 prevented phenobarbital resistant neonatal seizures a P7 and has positive long-term outcomes in adulthood on vEEG |
| Kipnis et al. (32427585) | 2020 | Unilateral carotid ligation in P7 CD-1, P10 CD-1, and P7 TrkBF616A pups | Video-EEG monitoring | Neonatal | Acute administration of with partial TrkB agonist LM22A-4, TrkB agonist HIOC, or the chemical-genetic inactivation of TrkB all prevented P7 phenobarbital resistant neonatal seizures |