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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Bone. 2021 Mar 16;147:115913. doi: 10.1016/j.bone.2021.115913

Figure 9.

Figure 9.

Bone of γOTKO mice is partially protected from the detrimental effects of rosiglitazone. A. Percent change in global BMD after 4 wks treatment of 10 mo old females with rosiglitazone (25 mg/kg/d). n=4–5 per group. B. μCT measurements of trabecular bone in L4 vertebrae and representative renderings. n=5–6/group. BV/TV – trabecular bone mass, Tb.N – trabecular number, Tb.Th – trabecular thickness, Tb.Sp – trabecular spacing. Bar on renderings indicates 0.1 mm. C. Left - Total fat volume in femora measured with μCT after decalcification and staining with OsO4 (n=5/group). Right - Representative mCT renderings. Bar on renderings indicates 1 mm. Statistical analysis was performed using Two-way Anova followed by Tukey’s multiple comparison test and p values are indicated over horizontal lines on graphs.