Table 1.
Means and standard deviations of the values of the cell bodies areas and density of HUC/D-IR and nNOS-IR neurons and VIP-IR, CGRP-IR, and SP-IR values of myenteric neurons varicosities areas of the ileum of rats subchronically exposed, or not exposed, to fluoride in the drinking water.
| ANALYSIS | Control | 10 mgF/L | 50 mgF/L |
|---|---|---|---|
| Cell bodies areas of the HuC/D-IR neurons (µm2) | 315.1±4.0a | 311.8±3.9a | 321.6±3.6a |
| Density HuC/D-IR neurons (neurons/cm2) | 16.626,7±493.6a | 14.990,2±419.1b | 14.615,6±461.9b |
| Cell bodies areas of the nNOS-IR neurons (µm2) | 293.1±3.1a | 300.0±3.4a | 290.2±3.2a |
| Density nNOS-IR neurons (neurons/cm2) | 4.563,4±130.5a | 4.334,9±119.6a | 4.353,9±136.1a |
| Area VIP-IR varicosities (µm2) | 3.55±0.03a | 3.55±0.04a | 4.67±0.05b |
| Area CGRP-IR varicosities (µm2) | 3.24±0.02a | 3.42±0.03b | 3.58±0.03c |
| Area SP-IR varicosities (µm2) | 2.89±0.02a | 4.58±0.02b | 4.64±0.03b |
Means followed by distinct letters in the same line are significantly different according to ANOVA followed by Fisher’s test (density HuC/D-IR and nNOS-IR neurons) or ANOVA followed by Tukey’s test (other variables). p <0.05. n = 6.