Table 4.
Hazard ratios and 95% CI for the association of baseline BIA-derived baseline body fat measures with risk of incident, invasive colorectal cancer among men and women (combined) in the UK Biobank.
| Body fat measures | Colorectal N = 843 | Colon N = 541 | Rectal N = 302 | |||
|---|---|---|---|---|---|---|
| Cases/incidence per 1000PY | Multivariable-adjusted HR (95% CI) | Cases/incidence per 1000PY | Multivariable-adjusted HR (95% CI) | Cases/incidence per 1000PY | Multivariable-adjusted HR (95% CI) | |
| FMI (kg/m2) | ||||||
| Q1 | 161/0.64 | 1.00 | 104/0.41 | 1.00 | 57/0.23 | 1.00 |
| Q2 | 161/0.73 | 1.05 (0.84–1.31) | 104/0.47 | 1.04 (0.80–1.37) | 57/0.26 | 1.06 (0.73–1.53) |
| Q3 | 178/0.87 | 1.16 (0.94–1.44) | 116/0.56 | 1.17 (0.90–1.53) | 62/0.30 | 1.15 (0.80–1.66) |
| Q4 | 169/0.89 | 1.13 (0.91–1.40) | 106/0.56 | 1.08 (0.82–1.42) | 63/0.33 | 1.22 (0.85–1.75) |
| Q5 | 174/1.00 | 1.14 (0.92–1.42) | 111/0.64 | 1.11 (0.85–1.46) | 63/0.36 | 1.19 (0.83–1.72) |
| Ptrenda | 0.18 | 0.44 | 0.24 | |||
| Body fat % | ||||||
| Q1 | 155/0.63 | 1.00 | 98/0.40 | 1.00 | 57/0.23 | 1.00 |
| Q2 | 160/0.70 | 0.99 (0.80–1.25) | 109/0.48 | 1.07 (0.81–1.41) | 51/0.22 | 0.87 (0.60–1.28) |
| Q3 | 188/0.90 | 1.19 (0.96–1.48) | 116/0.55 | 1.15 (0.88–1.51) | 72/0.34 | 1.27 (0.89–1.80) |
| Q4 | 154/0.84 | 1.02 (0.82–1.28) | 102/0.55 | 1.06 (0.80–1.40) | 52/0.28 | 0.96 (0.66–1.41) |
| Q5 | 186/1.07 | 1.17 (0.94–1.45) | 116/0.66 | 1.14 (0.86–1.50) | 70/0.40 | 1.23 (0.86–1.76) |
| Ptrenda | 0.18 | 0.44 | 0.22 | |||
| Whole body fat mass to whole body fat free mass | ||||||
| Q1 | 154/0.64 | 1.00 | 98/0.41 | 1.00 | 56/0.23 | 1.00 |
| Q2 | 160/0.70 | 0.99 (0.79–1.24) | 109/0.48 | 1.05 (0.80–1.39) | 51/0.22 | 0.88 (0.60–1.28) |
| Q3 | 186/0.89 | 1.17 (0.95–1.45) | 114/0.55 | 1.12 (0.85–1.47) | 72/0.35 | 1.27 (0.89–1.80) |
| Q4 | 150/0.83 | 1.00 (0.80–1.26) | 100/0.55 | 1.04 (0.78–1.37) | 50/0.28 | 0.94 (0.64–1.38) |
| Q5 | 193/1.06 | 1.15 (0.93–1.43) | 120/0.66 | 1.11 (0.84–1.44) | 73/0.40 | 1.23 (0.86–1.75) |
| Ptrenda | 0.22 | 0.54 | 0.23 | |||
| BMI (kg/m2) | ||||||
| Q1 | 164/0.71 | 1.00 | 113/0.49 | 1.00 | 51/0.22 | 1.00 |
| Q2 | 184/0.82 | 1.12 (0.90–1.38) | 106/0.48 | 0.94 (0.72–1.22) | 78/0.35 | 1.50 (1.06–2.14) |
| Q3 | 158/0.84 | 1.14 (0.92–1.42) | 105/0.56 | 1.08 (0.83–1.41) | 53/0.28 | 1.27 (0.86–1.87) |
| Q4 | 183/0.87 | 1.10 (0.89–1.37) | 111/0.53 | 0.98 (0.75–1.28) | 72/0.34 | 1.37 (0.95–1.97) |
| Q5 | 154/0.82 | 1.05 (0.84–1.31) | 106/0.57 | 1.04 (0.80–1.36) | 48/0.26 | 1.07 (0.72–1.59) |
| Ptrenda | 0.70 | 0.68 | 0.94 | |||
| TFMI (kg/m2) | ||||||
| Q1 | 159/0.65 | 1.00 | 103/0.42 | 1.00 | 56/0.23 | 1.00 |
| Q2 | 166/0.72 | 1.00 (0.81–1.25) | 109/0.47 | 1.02 (0.78–1.33) | 57/0.25 | 0.98 (0.68–1.42) |
| Q3 | 178/0.86 | 1.12 (0.90–1.39) | 108/0.52 | 1.04 (0.79–1.37) | 70/0.34 | 1.26 (0.88–1.79) |
| Q4 | 164/0.88 | 1.08 (0.87–1.35) | 112/0.60 | 1.12 (0.86–1.47) | 52/0.28 | 0.99 (0.68–1.46) |
| Q5 | 176/1.03 | 1.13 (0.90–1.41) | 109/0.64 | 1.07 (0.81–1.41) | 67/0.39 | 1.24 (0.86–1.78) |
| Ptrenda | 0.21 | 0.45 | 0.29 | |||
| Trunk fat % | ||||||
| Q1 | 162/0.67 | 1.00 | 106/0.44 | 1.00 | 56/0.23 | 1.00 |
| Q2 | 164/0.69 | 0.92 (0.74–1.15) | 102/0.43 | 0.89 (0.68–1.17) | 62/0.26 | 1.06 (0.73–1.52) |
| Q3 | 181/0.88 | 1.12 (0.90–1.38) | 120/0.58 | 1.14 (0.87–1.48) | 61/0.30 | 1.12 (0.78–1.61) |
| Q4 | 159/0.85 | 1.02 (0.82–1.28) | 102/0.55 | 0.99 (0.75–1.30) | 57/0.31 | 1.08 (0.75–1.58) |
| Q5 | 177/1.04 | 1.12 (0.90–1.40) | 111/0.65 | 1.07 (0.81–1.40) | 66/0.39 | 1.25 (0.87–1.80) |
| Ptrenda | 0.20 | 0.45 | 0.25 | |||
| Per SD increase | ||||||
| Trunk fat to trunk fat free mass | ||||||
| Q1 | 160/0.67 | 1.00 | 104/0.44 | 1.00 | 56/0.24 | 1.00 |
| Q2 | 159/0.68 | 0.91 (0.73–1.14) | 103/0.44 | 0.91 (0.69–1.19) | 56/0.24 | 0.95 (0.65–1.37) |
| Q3 | 181/0.88 | 1.10 (0.89–1.37) | 118/0.57 | 1.11 (0.85–1.45) | 63/0.30 | 1.13 (0.79–1.62) |
| Q4 | 162/0.86 | 1.01 (0.81–1.25) | 102/0.54 | 0.98 (0.74–1.29) | 60/0.32 | 1.10 (0.76–1.60) |
| Q5 | 181/1.04 | 1.10 (0.88–1.36) | 114/0.65 | 1.07 (0.82–1.41) | 67/0.38 | 1.22 (0.85–1.76) |
| Ptrenda | 0.17 | 0.48 | 0.18 | |||
| Leg fat mass (kg) | ||||||
| Q1 | 216/0.99 | 1.00 | 117/0.44 | 1.00 | 73/0.27 | 1.00 |
| Q2 | 163/0.82 | 1.01 (0.82–1.24) | 115/0.51 | 1.07 (0.83–1.39) | 59/0.26 | 0.90 (0.64–1.27) |
| Q3 | 176/0.85 | 1.05 (0.85–1.29) | 108/0.52 | 1.05 (0.81–1.37) | 64/0.31 | 1.03 (0.74–1.45) |
| Q4 | 159/0.77 | 0.99 (0.79–1.23) | 95/0.54 | 1.04 (0.79–1.37) | 48/0.27 | 0.89 (0.61–1.29) |
| Q5 | 129/0.60 | 1.08 (0.86–1.34) | 106/0.63 | 1.14 (0.86–1.50) | 58/0.34 | 0.98 (0.68–1.41) |
| Ptrenda | 0.62 | 0.47 | 0.91 | |||
| Per SD increase | ||||||
| Ratio of trunk fat mass to leg fat mass | ||||||
| Q1 | 157/0.65 | 1.00 | 103/0.45 | 1.00 | 54/0.24 | 1.00 |
| Q2 | 161/0.66 | 0.97 (0.77–1.20) | 105/0.47 | 0.96 (0.71–1.23) | 56/0.25 | 0.98 (0.67–1.42) |
| Q3 | 179/0.89 | 1.06 (0.85–1.32) | 123/0.56 | 1.09 (0.83–1.42) | 60/0.27 | 0.99 (0.69–1.44) |
| Q4 | 159/0.85 | 1.08 (0.86–1.34) | 102/0.50 | 0.95 (0.73–1.28) | 73/0.36 | 1.31 (0.91–1.88) |
| Q5 | 187/1.12 | 1.25 (0.99–1.58) | 108/0.65 | 1.22 (0.82–1.44) | 59/0.35 | 1.32 (0.89–1.94) |
| Ptrenda | 0.04 | 0.26 | 0.05 | |||
| WC (cm) | ||||||
| Q1 | 183/0.65 | 1.00 | 114/0.41 | 1.00 | 69/0.25 | 1.00 |
| Q2 | 168/0.71 | 1.07 (0.86–1.32) | 107/0.45 | 1.06 (0.81–1.38) | 61/0.26 | 1.08 (0.76–1.52) |
| Q3 | 165/0.84 | 1.16 (0.94–1.43) | 108/0.55 | 1.21 (0.93–1.58) | 57/0.29 | 1.07 (0.75–1.52) |
| Q4 | 173/1.05 | 1.34 (1.09–1.66) | 108/0.65 | 1.36 (1.04–1.78) | 65/0.39 | 1.31 (0.92–1.85) |
| Q5 | 154/0.94 | 1.16 (0.93–1.45) | 104/0.64 | 1.23 (0.93–1.62) | 50/0.31 | 1.04 (0.71–1.53) |
| Ptrenda | 0.03 | 0.03 | 0.45 | |||
| WHR | ||||||
| Q1 | 155/0.63 | 1.00 | 95/0.39 | 1.00 | 60/0.24 | 1.00 |
| Q2 | 148/0.67 | 0.99 (0.79–1.25) | 99/0.45 | 1.09 (0.82–1.44) | 49/0.22 | 0.85 (0.58–1.24) |
| Q3 | 186/0.90 | 1.24 (1.00–1.54) | 115/0.55 | 1.25 (0.95–1.65) | 71/0.34 | 1.22 (0.87–1.73) |
| Q4 | 175/0.93 | 1.24 (0.99–1.54) | 114/0.61 | 1.30 (0.99–1.71) | 61/0.32 | 1.15 (0.80–1.64) |
| Q5 | 179/1.00 | 1.24 (0.99–1.54) | 118/0.66 | 1.31 (0.99–1.72) | 61/0.34 | 1.12 (0.78–1.61) |
| Ptrenda | 0.001 | 0.02 | 0.23 | |||
All models were adjusted for age at enrollment, education, physical activity, alcohol intake, smoking, history of diabetes, height, red meat intake, processed meat intake, fruits and vegetable intake, folate supplement intake, Vitamin D supplement intake.
Ranges:
Men: FMI: ≤ 3.7, 3.8–4.5, 4.6–5.1, 5.2–5.7, >5.7; body fat %: ≤16.4, 16.5–19.2, 19.3–21.4, 21.5–23.7, >23.7; whole body fat to whole body fat free mass: ≤0.20, 0.21–0.24, 0.25–0.27, 0.28–0.31, >0.31; BMI: ≤ 22.1, 22.2–23.3, 23.4–23.8, 23.9–24.5, >24.5; TFMI: ≤ 2.22; 2.23–2.81, 2.82–3.25, 3.25–3.68, >3.68; trunk fat %: ≤17.2, 17.3–20.9, 21.0–23.7, 23.8–26.6, >26.6; trunk fat mass to trunk fat free mass: ≤0.20, 0.21–0.26, 0.27–0.31, 0.31–0.36, >0.36; leg fat mass: ≤3.3, 3.4–3.8, 3.9–4.2, 4.3–4.6, >4.6; ratio of trunk fat mass to leg fat mass: ≤1.93, 1.94–2.21, 2.22–2.44, 2.45–2.69, >2.69; WC: ≤ 82, 83–85, 86–88, 89–92, >92; WHR: ≤ 0.85, 0.86–0.88, 0.89–0.91, 0.92–0.94, >0.94 for quintiles 1,2 3, 4, and 5, respectively.
Women: FMI: ≤ 6.0, 6.1–6.9, 7.0–7.6, 7.7–8.4, >8.4; body fat %: ≤27.4, 27.5–30.5, 30.6–32.8, 32.9–35.1, >35.1; whole body fat to whole body fat free mass: ≤0.38, 0.39–0.44, 0.45–0.49, 0.50–0.54,> 0.54; BMI: ≤ 21.4, 21.5–22.6, 22.7–23.5, 23.6–24.2, >24.2; TFMI: ≤ 2.86; 2.87–3.44, 3.45–3.90, 3.91–4.39, >4.39; trunk fat %: ≤23.8, 23.9–27.8, 27.9–30.6, 30.7–33.6, >33.6; trunk fat mass to trunk fat free mass: ≤0.31, 0.32–0.38, 0.39–0.44, 0.45–0.50, >0.50; leg fat mass: ≤6.8, 6.9–7.6, 7.7–8.2, 8.3–8.8, >8.8; ratio of trunk fat mass to leg fat mass: ≤1.06, 1.07–1.19, 1.20–1.30, 1.31–1.42, >1.43; WC: ≤ 70, 71–74, 75–77, 78–80.3, >80.3; WHR: ≤ 0.74, 0.75–0.77, 0.78–0.80, 0.81–0.83, >0.83 for quintiles 1,2 3, 4, and 5, respectively.
PY person-year, CI confidence interval, HR hazard ratio, SD standard deviation, FMI fat mass index, TFMI trunk fat mass index.
aAll tests were two-sided.