Table 6.
Hazard ratios and 95% CI for the association of baseline BIA-derived measures of body fat with risk of incident, invasive colorectal cancer among participants in the UK Biobank (excluding participants within two years of recruitment).
| Colorectal | Colon | Rectal | |
|---|---|---|---|
| FMI (kg/m2) | |||
| Q1 | 1.00 | 1.00 | 1.00 |
| Q2 | 1.03 (0.80–1.32) | 1.06 (0.78–1.45) | 0.96 (0.62–1.47) |
| Q3 | 1.04 (0.81–1.33) | 1.09 (0.80–1.48) | 0.94 (0.61–1.45) |
| Q4 | 1.07 (0.83–1.38) | 0.99 (0.73–1.37) | 1.21 (0.80–1.83) |
| Q5 | 1.15 (0.90–1.48) | 1.08 (0.79–1.48) | 1.30 (0.86–1.96) |
| Ptrenda | 0.24 | 0.78 | 0.11 |
| Body fat % | |||
| Q1 | 1.00 | 1.00 | 1.00 |
| Q2 | 0.96 (0.74–1.23) | 1.06 (0.78–1.44) | 0.78 (0.50–1.21) |
| Q3 | 1.09 (0.85–1.39) | 1.07 (0.78–1.46) | 1.12 (0.74–1.69) |
| Q4 | 0.99 (0.76–1.28) | 1.01 (0.73–1.40) | 0.94 (0.61–1.46) |
| Q5 | 1.16 (0.90–1.48) | 1.08 (0.79–1.48) | 1.30 (0.86–1.95) |
| Ptrenda | 0.25 | 0.77 | 0.13 |
| Whole body fat mass to whole body fat free mass | |||
| Q1 | 1.00 | 1.00 | 1.00 |
| Q2 | 0.94 (0.73–1.21) | 1.04 (0.77–1.42) | 0.76 (0.49–1.19) |
| Q3 | 1.06 (0.82–1.36) | 1.03 (0.75–1.41) | 1.10 (0.73–1.66) |
| Q4 | 0.95 (0.73–1.24) | 0.99 (0.71–1.37) | 0.89 (0.57–1.39) |
| Q5 | 1.14 (0.89–1.46) | 1.07 (0.78–1.46) | 1.26 (0.84–1.89) |
| Ptrenda | 0.32 | 0.82 | 0.17 |
| BMI (kg/m2) | |||
| Q1 | 1.00 | 1.00 | 1.00 |
| Q2 | 1.09 (0.86–1.39) | 0.89 (0.66–1.21) | 1.56 (1.03–2.36) |
| Q3 | 1.09 (0.84–1.40) | 1.09 (0.81–1.48) | 1.05 (0.65–1.68) |
| Q4 | 1.09 (0.85–1.39) | 0.91 (0.67–1.23) | 1.50 (0.99–2.27) |
| Q5 | 1.02 (0.79–1.31) | 0.96 (0.70–1.30) | 1.16 (0.73–1.82) |
| Ptrenda | 0.90 | 0.84 | 0.64 |
| TFMI (kg/m2) | |||
| Q1 | 1.00 | 1.00 | 1.00 |
| Q2 | 0.99 (0.77–1.27) | 1.06 (0.79–1.44) | 0.85 (0.55–1.31) |
| Q3 | 0.99 (0.77–1.28) | 0.92 (0.67–1.27) | 1.12 (0.74–1.69) |
| Q4 | 0.98 (0.75–1.26) | 1.05 (0.77–1.44) | 0.83 (0.53–1.31) |
| Q5 | 1.17 (0.91–1.50) | 1.07 (0.78–1.46) | 1.36 (0.91–2.04) |
| Ptrenda | 0.28 | 0.76 | 0.17 |
| Trunk fat % | |||
| Q1 | 1.00 | 1.00 | 1.00 |
| Q2 | 0.91 (0.71–1.17) | 0.91 (0.67–1.24) | 0.91 (0.59–1.39) |
| Q3 | 1.02 (0.80–1.31) | 1.03 (0.76–1.40) | 1.00 (0.66–1.53) |
| Q4 | 0.99 (0.77–1.28) | 1.01 (0.74–1.38) | 0.95 (0.61–1.47) |
| Q5 | 1.12 (0.87–1.44) | 1.01 (0.73–1.39) | 1.35 (0.90–2.02) |
| Ptrenda | 0.26 | 0.73 | 0.16 |
| Trunk fat mass to trunk fat free mass | |||
| Q1 | 1.00 | 1.00 | 1.00 |
| Q2 | 0.88 (0.68–1.13) | 0.91 (0.67–1.24) | 0.82 (0.53–1.26) |
| Q3 | 0.99 (0.78–1.28) | 0.99 (0.73–1.35) | 1.01 (0.66–1.53) |
| Q4 | 0.98 (0.76–1.26) | 0.98 (0.72–1.35) | 0.97 (0.63–1.49) |
| Q5 | 1.13 (0.88–1.45) | 1.03 (0.75–1.41) | 1.32 (0.88–1.98) |
| Ptrenda | 0.21 | 0.71 | 0.11 |
| Leg fat mass (kg) | |||
| Q1 | 1.00 | 1.00 | 1.00 |
| Q2 | 0.90 (0.71–1.15) | 1.04 (0.77–1.39) | 0.69 (0.45–1.05) |
| Q3 | 1.07 (0.84–1.35) | 1.06 (0.78–1.43) | 1.09 (0.74–1.59) |
| Q4 | 0.88 (0.68–1.14) | 0.93 (0.67–1.28) | 0.79 (0.51–1.22) |
| Q5 | 1.09 (0.85–1.40) | 1.12 (0.82–1.54) | 1.04 (0.69–1.56) |
| Ptrenda | 0.63 | 0.74 | 0.72 |
| Ratio of trunk fat mass to leg fat mass | |||
| Q1 | 1.00 | 1.00 | 1.00 |
| Q2 | 0.99 (0.77–1.28) | 0.99 (0.72–1.35) | 1.00 (0.66–1.53) |
| Q3 | 0.99 (0.77–1.28) | 1.13 (0.83–1.53) | 0.76 (0.49–1.20) |
| Q4 | 1.09 (0.84–1.41) | 1.00 (0.73–1.39) | 1.24 (0.82–1.87) |
| Q5 | 1.16 (0.88–1.52) | 1.07 (0.76–1.51) | 1.31 (0.85–2.04) |
| Ptrenda | 0.22 | 0.70 | 0.12 |
| WC (cm) | |||
| Q1 | 1.00 | 1.00 | 1.00 |
| Q2 | 1.01 (0.80–1.29) | 0.97 (0.72–1.31) | 1.11 (0.73–1.67) |
| Q3 | 1.17 (0.92–1.49) | 1.06 (0.79–1.44) | 1.37 (0.92–2.04) |
| Q4 | 1.21 (0.94–1.55) | 1.17 (0.86–1.60) | 1.27 (0.84–1.93) |
| Q5 | 1.12 (0.86–1.45) | 1.13 (0.83–1.55) | 1.08 (0.69–1.69) |
| Ptrenda | 0.16 | 0.23 | 0.48 |
| WHR | |||
| Q1 | 1.00 | 1.00 | 1.00 |
| Q2 | 0.94 (0.72–1.22) | 1.04 (0.76–1.44) | 0.77 (0.49–1.21) |
| Q3 | 1.27 (0.99–1.62) | 1.23 (0.90–1.68) | 1.33 (0.90–1.97) |
| Q4 | 1.17 (0.91–1.51) | 1.26 (0.92–1.72) | 1.02 (0.66–1.57) |
| Q5 | 1.21 (0.94–1.56) | 1.21 (0.88–1.66) | 1.21 (0.80–1.84) |
| Ptrenda | 0.04 | 0.12 | 0.19 |
All models were adjusted for age at enrollment, education, physical activity, alcohol intake, smoking, height, history of diabetes, red meat intake, processed meat intake, fruits and vegetable intake, folate supplement intake, Vitamin D supplement intake.
aAll tests were two-sided.
Ranges:
Men: FMI: ≤ 3.7, 3.8–4.5, 4.6–5.1, 5.2–5.7, >5.7; body fat %: ≤16.4, 16.5–19.2, 19.3–21.4, 21.5–23.7, >23.7; whole body fat to whole body fat free mass: ≤0.20, 0.21–0.24, 0.25–0.27, 0.28–0.31, >0.31; BMI: ≤ 22.1, 22.2–23.3, 23.4–23.8, 23.9–24.5, >24.5; TFMI: ≤ 2.22; 2.23–2.81, 2.82–3.25, 3.25–3.68, >3.68; trunk fat %: ≤17.2, 17.3–20.9, 21.0–23.7, 23.8–26.6, >26.6; trunk fat mass to trunk fat free mass: ≤0.20, 0.21–0.26, 0.27–0.31, 0.31–0.36, >0.36; leg fat mass: ≤3.3, 3.4–3.8, 3.9–4.2, 4.3–4.6, >4.6; ratio of trunk fat mass to leg fat mass: ≤1.93, 1.94–2.21, 2.22–2.44, 2.45–2.69, >2.69; WC: ≤ 82, 83–85, 86–88, 89–92, >92; WHR: ≤ 0.85, 0.86–0.88, 0.89–0.91, 0.92–0.94, >0.94 for quintiles 1,2 3, 4, and 5, respectively.
Women: FMI: ≤ 6.0, 6.1–6.9, 7.0–7.6, 7.7–8.4, >8.4; body fat %: ≤27.4, 27.5–30.5, 30.6–32.8, 32.9–35.1, >35.1; whole body fat to whole body fat free mass: ≤0.38, 0.39–0.44, 0.45–0.49, 0.50–0.54,> 0.54; BMI: ≤ 21.4, 21.5–22.6, 22.7–23.5, 23.6–24.2, >24.2; TFMI: ≤ 2.86; 2.87–3.44, 3.45–3.90, 3.91–4.39, >4.39; trunk fat %: ≤23.8, 23.9–27.8, 27.9–30.6, 30.7–33.6, >33.6; trunk fat mass to trunk fat free mass: ≤0.31, 0.32–0.38, 0.39–0.44, 0.45–0.50, >0.50; leg fat mass: ≤6.8, 6.9–7.6, 7.7–8.2, 8.3–8.8, >8.8; ratio of trunk fat mass to leg fat mass: ≤1.06, 1.07–1.19, 1.20–1.30, 1.31–1.42, >1.43; WC: ≤ 70, 71–74, 75–77, 78–80.3, >80.3; WHR: ≤ 0.74, 0.75–0.77, 0.78–0.80, 0.81–0.83, >0.83 for quintiles 1,2 3, 4, and 5, respectively.
HR hazard ratio, CI confidence interval, BMI body mass index, WC waist circumference, WHR waist to hip ratio, FMI fat mass index, TFMI trunk fat mass index.
aAll tests were two-sided.