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. 2021 Apr 26;11:8998. doi: 10.1038/s41598-021-88318-0

Table 1.

Concordance tests between phenotypic antimicrobial susceptibility testing and WGS-based predicted antimicrobial resistance.

Antimicrobial agent Sensitivity Specificity Predictive value +  Predictive value −  Cohen's kappa coefficient
% 95% CI % 95% CI % 95% CI % 95% CI κ 95% CI p value Interpretation
Ampicillin (AMP)a 96.0 80.5 to 99.3 96.0 88.4 to 99.6 96.0 80.5 to 99.3 97.8 88.4 to 99.6 0.94 0.85 to 1.00  < 0.001 Very Good
Ciprofloxacin (CIP) 98.2 90.7 to 99.7 100.0 75.8 to 100 100.0 93.6 to 100 92.3 66.7 to 98.6 0.95 0.86 to 1.00  < 0.001 Very Good
Nalidixic acid (NAL) 100.0 93.6 to 100 100.0 77.2 to 100 100.0 93.6 to 100 100.0 77.2 to 100 1.00 1.00 to 1.00  < 0.001 Very Good
Erythromycin (ERY) 100.0 64.6 to 100 100.0 94.2 to 100 100.0 64.6 to 100 100.0 94.2 to 100 1.00 1.00 to 1.00  < 0.001 Very Good
Gentamicin (GEN) 100.0 61.0 to 100 100.0 94.3 to 100 100.0 61.0 to 100 100.0 94.3 to 100 1.00 1.00 to 1.00  < 0.001 Very Good
Streptomycin (STR) 96.2 81.1 to 99.3 95.3 84.5 to 98.7 92.6 76.6 to 97.9 97.6 87.7 to 99.6 0.91 0.81 to 1.00  < 0.001 Very Good
Tetracycline (TET) 100.0 93.6 to 100 100.0 77.2 to 100 100.0 93.6 to 100 100.0 77.2 to 100 1.00 1.00 to 1.00  < 0.001 Very Good

aPresence of blaOXA-61-like gene with T at the promoter region (57 bp upstream of the start codon) and/or presence of blaOXA-184 gene.