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. 2021 Apr 26;11:9008. doi: 10.1038/s41598-021-88516-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Epigenome-wide clustering of MYB. (A) Heatmap displaying the current MYB ChIP-seq signal, public ChIP-seq signals for H3K4me1 (GSM733692), H3K4me3 (GSM733680), H3K27ac (GSM733656), H3K36me3 (GSM733714), and H3K27me3 (GSM733658) ChIP-seq, and ATAC-seq signal from our previous data (GEO accession: GSE92871) within a 4 kb window around the summit of MYB bound regions. We identified five clusters as indicated on the heatmaps, generated by ChAsE 1.1.2⁴⁶ (termed C1-C5 in the figure). (B) Distribution of MYB binding sites between TSS/promoter, gene body or distal regions in each cluster C1-C5. (C) An upset plot showing overlaps of the number of genes associated with each C-group. The upset plot was generated using the Intervene upset module v0.6.4⁷⁸.