Table 2.

Hazard ratios for death from breast cancer for selected variables.

Variables	Cases/total	Univariate HR (95% CI) P value	Multivariatea HR (95% CI) P value
Age at diagnosis
<=40	38/243	1	1
41–50	31/252	0.81 (0.51–1.31) 0.39	0.94 (0.58–1.53) 0.81
50+	22/169	1.00 (0.60–1.79) 0.97	1.01 (0.58–1.75) 0.98
BC size
<=10	7/127	1	1
11–20	31/222	2.95 (1.30–6.69) 0.01	2.41 (1.04–5.58) 0.04
>20	39/233	4.09 (1.83–19.2) 0.0006	3.13 (1.33–7.35) 0.009
Endocrine therapy
None	24/198	1	1
Tamoxifen alone	45/308	1.36 (0.83–2.23) 0.23	1.11 (0.62–1.98) 0.73
AI alone	6/49	1.45 (0.59–3.55) 0.42	1.56 (0.56–4.33) 0.40
Both	3/23	0.98 (0.30–3.26) 0.98	1.24 (0.35–4.42) 0.74
Either	54/380	1.34 (0.84–2.17) 0.23	1.13 (0.64–2.00) 0.67
Grade
1/2	34/248	0.97 (0.59–1.58) 0.89	1.17 (0.70–1.96) 0.55
3	31/236	1	1
ER status
Negative	12/107	1	1
Positive	60/455	1.29 (0.69–2.39) 0.43	1.23 (0.62–2.45) 0.55
Nodal status
Negative	34/310	1	1
Positive	48/278	1.83 (1.18–2.84) 0.007	1.67 (1.00–2.79) 0.05
Chemotherapy
No	19/165	1	1
Yes	54/419	1.24 (0.73–2.09) 0.42	0.83 (0.65–1.53) 0.56
Contralateral mastectomy
No	58/345	1	1
Yes	32/307	0.56 (0.36–0.88) 0.009	0.71 (0.44–1.15) 0.17
Missing	1/12
Oophorectomy
No	59/287	1	1
Yes	32/377	0.37 (0.24–0.58) <0.001	0.45 (0.28–0.72) 0.0009
Yes, within 1 year	8/82	0.45 (0.21–0.93) 0.03	0.56 (0.26–1.21) 0.14
Yes, 1–2 years after diagnosis	18/184	0.42 (0.25–0.71) 0.001	0.51 (0.29–0.91) 0.02
Yes, 3+ years after diagnosis	6/111	0.23 (0.10–0.55) 0.001	0.28 (0.12–0.67) 0.004
Yes, age at ooph <50	24/245	0.42 (0.26–0.67) 0.0004	0.51 (0.30–0.87) 0.01
Y, age at ooph >=50	8/132	0.28 (0.13–0.60) 0.0009	0.33 (0.15–0.74) 0.007

^aAdjusted by all the variables; the 12 subjects missing PM data were supposed as no PM in the estimation on the RR of factors other than PM.