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. 2021 Apr 26;11:8963. doi: 10.1038/s41598-021-88355-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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I194496 blocks the PI3K/Akt and Ras/Raf/ERK signaling pathways in human TNBC cells. (A, B) The effect of I194496 on PI3K/Akt pathway in MDA-MB-231 cells. *P < 0.05 vs 0 μM I194496 group. ^▲P < 0.05 vs 20 μM I194496 group. ^#P < 0.05 vs 30 μM I194496 group. (C, D) The effect of I194496 on PI3K/Akt pathway in MDA-MB-468 cells. *P < 0.05 vs 0 μM I194496 group. ^▲P < 0.05 vs 24 μM I194496 group. ^ΔP < 0.05 vs 28 μM I194496 group. (E, F) The effect of I194496 Ras/Raf/ERK pathway in MDA-MB-231 cells. *P < 0.05 vs 0 μM I194496 group. ^▲P < 0.05 vs 20 μM I194496 group. ^#P < 0.05 vs 30 μM I194496 group. (G, H) The effect of I194496 on Ras/Raf/ERK pathway in MDA-MB-468 cells. *P < 0.05 vs 0 μM I194496 group. ^▲P < 0.05 vs 24 μM I194496 group. ^ΔP < 0.05 vs 28 μM I194496 group.