Table 2.
Analysis of the risk factors for morbidity in 7 days, BPD, IVH, and PVL using multivariable mixed regression model.
| Mortality in 7 days | BPD | IVH | PVL | |
|---|---|---|---|---|
| Gestational age (week)a | ||||
| < 25 | 20.10(9.30–43.42) | 27.36(18.5–40.47) | 21.07(11.16–39.75) | 1.56(1.02–2.38) |
| 25–26+6 | 7.23(3.39–15.44) | 12.23(8.99–16.64) | 8.86(4.77–16.44) | 1.59(1.09–2.33) |
| 27–28+6 | 3.65(1.70–7.84) | 5.37(4.01–7.18) | 4.25(2.29–7.86) | 1.16(0.80–1.68) |
| 29–30+6 | 2.19(1.00–4.76) | 3.12(2.36–4.12) | 1.70(0.90–3.20) | 1.05(0.73–1.50) |
| Apgar score at 5 min | 0.80(0.75–0.85) | 0.84(0.81–0.88) | 0.89(0.85–0.94) | 0.92(0.87–0.97) |
| Highest level of resuscitationb | ||||
| Routine care | 0.17(0.05–0.51) | 0.32(0.18–0.56) | 0.44(0.21–0.94) | 0.46(0.24–0.87) |
| Oxygen supplementation | 0.03(0.004–0.26) | 0.26(0.15–0.44) | 0.19(0.08–0.46) | 0.50(0.28–0.90) |
| Positive pressure ventilation | 0.27(0.14–0.50) | 0.37(0.23–0.60) | 0.46(0.27–0.78) | 0.54(0.33–0.9) |
| Endotracheal intubation | 0.37(0.25–0.55) | 0.59(0.38–0.92) | 0.61(0.41–0.91) | 0.65(0.43–0.99) |
| Chest compression | 0.27(0.13–0.57) | 0.75(0.40–1.42) | 0.85(0.47–1.57) | 1.19(0.65–2.16) |
| Chorioamnionitis | 0.62(0.48–0.79) | |||
| Small for gestational age | 1.66(1.16–2.39) | 2.56(2.05–3.19) | ||
| Prenatal steroid | 0.55(0.42–0.71) | |||
| Surfactant use | 1.53(1.17–2.00) | 1.96(1.30–2.94) | ||
Only statistically significant variables (P < 0.05) are shown as adjusted odds ratio (95% confidential intervals).
BPD bronchopulmonary dysplasia, IVH intraventricular hemorrhage, PVL periventricular leukomalacia.
aGestational age ≥ 31 weeks is the reference level.
bEpinephrine use is the reference level.