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. 2021 Apr 26;11:8993. doi: 10.1038/s41598-021-88274-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Sequence and location of W164A-3S and EC26-2A4 peptides in the transmembrane glycoprotein of HIV-1 (gp41, HXB2 reference strain numbering, GenBank: AF033819.3). Epitope sequences are indicated in underlined letters^{18, 22, 52}. The W614A mutation in peptide W164A-3S is shown in red. The amino acid sequence of the heptad repeat 2 (HR2) region is indicated in bold letters (aa 628–665). TMD- transmembrane domain; FP- fusion peptide; HR1- heptad repeat 1. The membrane proximal external region (MPER) is shown in italic letters (aa 660–683)^{6, 16}. The epitope of the broadly neutralizing antibody 2F5 is boxed¹⁷. In gp120, V1-V5 are hipervariable regions and C1-C5 are conserved regions.