Table 6.

“KEGG 2019 Human” category of Enrichr for 53 genes (based on gene expression) and 200 genes (based on m6A) selected by applying KTD-based unsupervised FE to integration of gene expression and m6A profile. Fifteen terms with adjusted P-values less than 0.05 are listed.

Term	Overlap	P-value	Adjusted P-value
Gene expression
Ribosome	20/153	$2.13\times {10}^{-29}$	$6.55\times {10}^{-27}$
Thermogenesis	13/231	$2.59\times {10}^{-14}$	$3.99\times {10}^{-12}$
Oxidative phosphorylation	11/133	$4.44\times {10}^{-14}$	$4.56\times {10}^{-12}$
Parkinson disease	11/142	$9.22\times {10}^{-14}$	$7.10\times {10}^{-12}$
Glycolysis/gluconeogenesis	8/68	$9.16\times {10}^{-12}$	$5.64\times {10}^{-10}$
HIF-1 signaling pathway	6/100	$2.55\times {10}^{-7}$	$1.31\times {10}^{-5}$
Alzheimer disease	7/171	$3.27\times {10}^{-7}$	$1.44\times {10}^{-5}$
Huntington disease	6/193	$1.18\times {10}^{-5}$	$4.53\times {10}^{-4}$
Retrograde endocannabinoid signaling	5/148	$4.47\times {10}^{-5}$	$1.53\times {10}^{-3}$
Cardiac muscle contraction	4/78	$5.42\times {10}^{-5}$	$1.67\times {10}^{-3}$
Non-alcoholic fatty liver disease (NAFLD)	4/149	$6.52\times {10}^{-4}$	$1.83\times {10}^{-2}$
m6A
Glycolysis/gluconeogenesis	7/68	$5.21\times {10}^{-6}$	$1.60\times {10}^{-3}$
Central carbon metabolism in cancer	6/65	$4.69\times {10}^{-5}$	$7.22\times {10}^{-3}$
HIF-1 signaling pathway	6/100	$5.07\times {10}^{-4}$	$5.21\times {10}^{-2}$
Glucagon signaling pathway	6/103	$5.93\times {10}^{-4}$	$4.57\times {10}^{-2}$