Table 5. Proteins of the Top 20 Differentially Expressed Phosphorylated Peptides.
All peptides are also TMT modified.
| Gene | UniProt Accession | Protein | Peptide Position in Master Protein | Phosphorylations in Master Proteins (% localization probability if known) | Log2(AR HAP/LAP) |
|---|---|---|---|---|---|
| Increased in HAP vs LAP | |||||
| Ank2 | Q8C8R3 | Ankyrin-2 | 1815–1823 | 2xPhospho [S1816(100); S1819(100)] | 2.79 |
| Nefh | P19246 | Neurofilament heavy polypeptide | 565–582 | 2xPhospho [S571(100); S577(100)] | 1.75 |
| Ank2 | Q8C8R3 | Ankyrin-2 | 3217–3235 | 3xPhospho [S3226(100); S3229(100); S3230(100)] | 1.63 |
| Ank2 | Q8C8R3 | Ankyrin-2 | 1812–1823 | 2xPhospho [S1816(100); S1819(100)] | 1.14 |
| Nefh | P19246 | Neurofilament heavy polypeptide | 559–576 | 2xPhospho [S565(100); S571(100)] | 1.00 |
| Mapt | A0A0A0MQC7 | Microtubule-associated protein | 57–72 | 1xPhospho [T58(99.7)] | 0.98 |
| Bicc1 | G3X8S6 | Bicaudal C homolog 1 | 807–819 | 1xPhospho [S814(50); S819(50)} | 0.90 |
| Sgip1 | Q8VD37 | SH3-containing GRB2-like protein 3-interacting protein 1 | 76–99 | 1xPhospho [S95(100)] | 0.85 |
| Bsn | O88737 | Protein bassoon | 2858–2874 | 1xPhospho [S2860(100)] | 0.81 |
| Mical3 | Q8CJ19 | Protein-methionine sulfoxide oxidase MICAL3 | 515–520 | 1xPhospho [S517(100)] | 0.81 |
| Decreased in HAP vs LAP | |||||
| Ank2 | Q8C8R3 | Ankyrin-2 | 3763–3783 | 1xPhospho [S3781(91.5)] | −2.3 |
| Wdr37 | Q05BF4 | WD repeat-containing protein 37 | 20–26 | 2xPhospho [S22(100); S24(100)] | −1.39 |
| Dlg1 | D3Z3B8 | Disks large homolog 1 | 479–494 | 1xPhospho [S492(100)] | −1.39 |
| Amph | A0A0G2JEG8 | Amphiphysin | 495–509 | 1xPhospho [S504(100)] | −1.28 |
| Scg2 | Q03517 | Secretogranin-2 | 549–561 | 1xPhospho [S556(99.7)] | −1.21 |
| Naxe | Q8K4Z3 | NAD(P)H-hydrate epimerase | 41–52 | 1xPhospho [T45(89.4)] | −1.12 |
| Exoc7 | O35250 | Exocyst complex component 7 | 281–290 | 1xPhospho [S283(100)] | −1.1 |
| Scg2 | Q03517 | Secretogranin-2 | 549–561 | 1xPhospho [S556(99.7)] | −1.04 |
| Srsf10 | Q3TFP0 | Serine/arginine-rich-splicing factor 10 | 119–126 | 2xPhospho [S121(100); S123(100)] | −1.04 |
| Tgoln1 | Q62313 | Trans-Golgi network integral membrane protein 1 | 126–160 | 3xPhospho [S130(0.6); S131(32.8); T132(32.8); T135(32.8) | −0.99 |
AR, Abundance Ratio.