Table 1.

The Royal College of Paediatrics and Child Health (RCPCH) case definition of paediatric multisystem inflammatory syndrome temporally associated with COVID-19 [15]

RCPCH definition of MIS-C
1. A child presenting with persistent fever, inflammation (neutrophilia, elevated CRP and lymphopenia) and evidence of single or multi-organ dysfunction (shock, cardiac, respiratory, renal, gastrointestinal or neurologic disorder) with additional features. This may include children fulfilling full or partial criteria for Kawasaki disease
2. Exclusion of any other microbial cause, including bacterial sepsis, staphylococcal or streptococcal shock syndromes, infections associated with myocarditis such as enterovirus
3. SARS-CoV-2 PCR testing may be positive or negative

COVID-19 coronavirus disease 2019, CRP C-reactive protein, MIS-C multisystem inflammatory syndrome in children associated with COVID-19, PCR polymerase chain reaction, SARS-CoV-2 severe acute respiratory syndrome coronavirus 2