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. 2021 Apr 13;8:643793. doi: 10.3389/fmed.2021.643793

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Copyright © 2021 Koomullil, Tehrani, Goliwas, Wang, Ponnazhagan, Berry and Deshane.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Results from the simulation of interstitial fluid flow and exosome concentration in TME at two stages in tumor growth. Exosomes produced by the tumor cells at a constant rate are carried by the interstitial fluid flow and diffused based on the concentration gradient. (A) Predicted exosome concentration in an early stage. (B) Predicted exosome concentration in a later stage. The predicted concentration of exosomes is ~3.5 times greater for the later stage as compared to the early stage.