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Mechanisms of circRNA functions. There are five main action mechanisms of circRNAs, including (A) circRNAs can act as miRNAs sponge, (B) circRNAs can function as RBP sponges, (C) circRNAs mediated regulation of the transcription of parental genes, (D) circRNAs can be translated into proteins via some modification, and (E) circRNAs can act as dynamic scaffolding molecules that modulate protein-protein interactions.
