Table 1.
Circular RNAs in cardiovascular disease and regeneration.
| CVD type | CircRNAs | Source | Action mechanism | Regulation | References |
|---|---|---|---|---|---|
| Cardiac Hypertrophy | circRNA wwp1 | Mouse myocardial tissue | Sponge miR-23a | Down | (107). |
| circRNA HRCR | Mouse heart tissue | Sponge miR-223 | Down | (108). | |
| Myocardial Fibrosis | circ_LAS1L | Human cardiac fibroblasts | Sponge miR-125b | Down | (12) |
| circ_BMP2K | Cardiac fibroblast | Sponge miR-455-3p | Down | (109) | |
| circPAN3 | Rat myocardial tissue | Sponge miR-221 | Up | (110) | |
| circ ACAP2 | Rat cardiomyocytes cell lines | Sponge miR-29 | Up | (109). | |
| circRNA_010567 | Mouse cardiac fibroblasts | Sponge miR-141 | Up | (111) | |
| circRNA_000203 | Mouse cardiac fibroblasts | Sponge miR-26b-5p | Up | (112) | |
| circNFIB | Mouse heart tissue | Sponge miR-433 | Down | (113) | |
| circHIPK3 | Mouse cardiac fibroblasts | Sponge miR-29b-3p | UP | (114) | |
| Cardiomyocyte | circ-ITCH | Rat cardiomyocytes cell lines | Sponge miR-17-5p | Down | (115) |
| Apoptosis | circSAMD4A | Rat cardiomyocytes cell lines | Sponge miR-138-5p | Up | (116) |
| circPAN3 | Rat myocardial tissue / Rat | Sponge miR-31-5p | Down | (117) | |
| cardiomyocytes cell lines | |||||
| Rat myocardial tissue / Rat | Sponge miR-421 | Down | (118) | ||
| Mouse myocardial tissue | |||||
| circDLGAP4 | Human endothelial cell lines | Sponge miR-143 | Down | (119) | |
| circFndc3b | Mouse myocardial tissue | Sponge RBP FUS | Up | (8) | |
| circMAT2B | Rat cardiomyocytes cell lines | Sponge miR-134 | Up | (120) | |
| circNFIX | Rat cardiomyocytes cell lines | Unknown | Down | (121) | |
| circ ACAP2 | Rat cardiomyocytes cell lines | Sponge miR-29 | Up | (109) | |
| hsa_circ_0000064 | Rat myocardial tissue | Unknown | Up | (122) | |
| Coronary Heart | circDHCR24 | Human aortic vascular | Sponge miR-149 | Up | (20) |
| Disease | smooth muscle cell | ||||
| circZNF609 | Human peripheral blood | Unknow | Down | (19) | |
| circMAP3K5 | Human coronary artery | Sponge miR-22-3p | Down | (23) | |
| smooth muscle cells | |||||
| circRNA-100338 | Human endothelial cell lines | Sponge miRNA-200a-3p | Down | (17) | |
| hsa_circ_0089378 | Plasma | Sponge hsa-miR-130a-3p | Up | (21) | |
| hsa_circ_0083357 | |||||
| hsa_circ_0082824 | |||||
| hsa_circ_0068942 | |||||
| hsa_circ_0057576 | |||||
| hsa_circ_0054537 | |||||
| hsa_circ_0051172 | |||||
| hsa_circ_0032970 | |||||
| hsa_circ_0006323 | |||||
| Heart Failure | hsa_circ_0005565 | Human heart tissue | Unknown | Up | (16) |
| hsa_circ_0097435 | Human peripheral blood | Sponge Hsa_miR_609 | Up | (15) | |
| Sponge Hsa_miR_1294 | |||||
| Sponge Hsa_miR_6799_5P | |||||
| Sponge Hsa_miR_5000_5P | |||||
| Sponge Hsa_miR_96_5P | |||||
| Myocardial | circTLK1 | Mouse myocardial tissue | Sponge miR-214 | Up | (11) |
| Regeneration | circRNA CDR1as | Pig myocardial tissue | Sponge miR-7 | Up | (10) |
| circ003593 | Cardiomyocytes cell lines | Unknown | Up | (13) | |
| circ-0001273 | Human umbilical cord mesenchymal | Unknown | Down | (9) | |
| stem cells (UMSCs) | |||||
| circCDYL | Mouse myocardial tissue | Sponge miR-4793-5p | Down | (14) | |
| circFASTKD1 | Human endothelial cell lines | Sponge miR-106a | Down | (123) | |
| hsa_circ_0007623 | Human endothelial cell lines | Sponge miR-297 | Up | (124) | |
| circHipk3 | Mouse heart tissue | Sponge miR-133a | Up | (104) | |
| circRNA_0001379 | Mouse myocardial tissue | Sponge miR-17-5p | Up | (103) |