Table 2.

Pooled odds ratio of toxicities in included randomized trials.

Toxicities	No. of trials	Events in EGFR-TKI + Chemotherapy group	Events in EGFR-TKI monotherapy group	Odds Ratio(95% CI)	Pvalue	Heterogeneity (I2) (%)
Leukopenia
Grades 1–2	4	117/426	24/362	5.72 (3.59–9.12)	<0.001	45
Grade ≥3	5	57/471	6/407	6.98 (0.93–52.38)	0.06	75
Neutropenia
Grades 1–2	4	143/500	11/447	16.84 (9.04–31.36)	<0.001	48
Grade ≥3	5	118/545	12/492	10.03 (1.04–96.69)	0.05	87
Thrombocytopenia
Grades 1–2	4	164/464	39/467	7.04 (4.73–10.48)	<0.001	0
Grade ≥3	5	37/509	0/512	43.41 (6.01–313.71)	<0.001	0
Anemia
Grades 1–2	5	261/590	158/532	3.01 (1.72–5.28)	<0.001	58
Grade ≥3	6	74/635	7/577	11.48 (5.35–24.59)	<0.001	0
Liver dysfunction
Grades 1–2	5	308/590	206/532	1.71 (1.34–2.19)	<0.001	0
Grade ≥3	6	82/635	63/577	1.56 (0.74–3.31)	0.25	68
Rash
Grades 1–2	5	342/590	312/532	0.96 (0.55–1.68)	0.90	78
Grade ≥3	6	27/635	23/577	1.14 (0.64–2.01)	0.66	0
Diarrhea
Grades 1–2	5	226/590	182/532	1.15 (0.90–1.47)	0.26	47
Grade ≥3	6	35/635	19/577	1.94 (1.08–3.47)	0.03	0
Fatigue
Grades 1–2	5	272/590	126/532	3.69 (1.99–6.85)	<0.001	71
Grade ≥3	6	25/635	7/577	2.80 (1.29–6.07)	0.009	13
Anorexia
Grades 1–2	5	310/590	132/532	4.00 (3.06–5.25)	<0.001	10
Grade ≥3	6	19/635	2/577	6.12 (1.79–21.00)	0.004	0
Nausea and vomiting
Grades 1–2	5	227/590	61/532	6.01 (2.94–12.26)	<0.001	74
Grade ≥3	6	20/635	4/577	4.10 (1.53–11.01)	0.005	0