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. 2021 Apr 13;12:650708. doi: 10.3389/fimmu.2021.650708

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Copyright © 2021 Dang, Lu, Chen and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Baricitinib reduces pathological tissue injuries in experimental autoimmune encephalomyelitis (EAE) mice. The extent of demyelination was semi-quantitatively analyzed. The results from each group are displayed as representative images, and the statistics of infiltration and demyelination are shown. Demyelination of the central nervous system (CNS) was evaluated by Luxol Fast Blue (LFB) (A) and myelin basic protein (MBP) (B). Cell nuclei were counterstained with DAPI (blue). Demyelination of the CNS was remarkedly reduced in the baricitinib-treated groups compared to that in the control group. The mean percentage of the microscopic fields with the lumbar spinal cord. Quantitative data are the mean ± SEM. *p < 0.05; n = 6 per group. SEM, standard error of the mean.