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. 2021 Apr 13;12:650708. doi: 10.3389/fimmu.2021.650708

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Copyright © 2021 Dang, Lu, Chen and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Baricitinib affects the differentiation of T-cells in CNS. At the peak phase of experimental autoimmune encephalomyelitis (EAE), CNS cells were isolated for flow cytometry to analyze changes in the differentiation of lymphocytes in spinal cord. The proportions of CD4+IFN-γ+Th1 (A), CD4+IL-4+Th2 (B), CD4+IL-17+ Th17 (C) and CD4+CD25+Foxp3+ Treg cells (D) of mice from different groups were investigated through flow cytometry analysis. The percentages of CD4+IFN-γ+ Th1 cells and CD4+IL-17+ Th17 cells in the CNS cells were decreased in both the baricitinib-treated groups than in the control group. Compared with the control group, baricitinib treatment did not affect the differentiation of CD4+IL-4+Th2 cells and CD4+CD25+Foxp3+ Treg cells. Quantitative data are the mean ± SEM. *p < 0.05; n = 6 per group.