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. 2021 Apr 13;12:650708. doi: 10.3389/fimmu.2021.650708

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Copyright © 2021 Dang, Lu, Chen and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Baricitinib treatment alters the cytokine profiles. Splenic mononuclear cells (MNCs) were isolated on the peak day. Cytokine profiles of supernatants cultured with MOG 35-55 peptide (10 μg/mL) for 72 h were investigated with ELISA kits. (A–L) The levels of IL-2, IL-6, IL-12, IL-17, IL-23, IFN-γ, and TNF-α significantly reduced in the baricitinib treatment groups compared with those in the vehicle group. However, levels of IL-4, IL-5, IL-10, TGFβ, and IL-13 were not significantly different. Quantitative data are the mean ± SEM. *p < 0.05; n = 6 per group. SEM, standard error of the mean.