Figure 4.

Comparison of retinal arterial and venous responses in the two genotypes. Shown are average arterial (turquoise) and venous (purple) responses to flicker light recorded in (A) Ca_v2.3-competent [Ca_v2.3_[+/+]: n = 15 and 22 animals for arterial and venous responses, respectively] or (B) Ca_v2.3-deficient [Ca_v2.3_[−/−]: n = 10 and 11 animals for arterial and venous responses, respectively]. Black dotted lines show the same data after smoothing with a 2-points FFT filter (cut-of frequency: 0.25) to remove high-frequency noise. Note that venous dilation during the flicker was consistently more pronounced than arterial dilation and that average responses in both vascular compartments were reduced in Ca_v2.3_[−/−] mice.