Table 1.
Multiple functions exerted by YTH family proteins in various cancers.
| Molecule | Cancer type | Target | Effect on target | Role in cancer | Reference |
|---|---|---|---|---|---|
| YTHDF1 | HCC | Snail | Translation | Promote EMT of HCC cells | (59) |
| HCC | FZD5 | Translation | Promote cell proliferation and metastasis | (60) | |
| Gastric cancer | FZD7 | Translation | Promote cell proliferation | (61) | |
| Lung cancer | CDK2, CDK4, cyclin D1 | Translation | Promote cell proliferation | (62) | |
| Ovarian cancer | EIF3C | Translation | Promote cell proliferation and metastasis | (63) | |
| Ovarian cancer | TRIM29 | Translation | Enhance CSC-like characteristics | (64) | |
| Ocular melanoma | HINT2 | Translation | Inhibit cell proliferation and migration | (65) | |
| MCC | eIF3 | Translation | Promote cell proliferation | (66) | |
| YTHDF2 | HCC | OCT4 | Translation | Promote CSC phenotype and metastasis | (67) |
| HCC | EGFR | Degradation | Inhibit cell proliferation | (68) | |
| HCC | IL11, SERPINE2 | Degradation | Inhibit inflammation, vascular remodeling and metastasis | (69) | |
| Pancreatic cancer | YAP | Expression | Promote cell proliferation but inhibit migration and invasion | (70) | |
| Gastric cancer | FOXC2 | Expression | Inhibit cell proliferation, invasion and migration | (71) | |
| CRC | XIST | Degradation | Inhibit cell proliferation and metastasis | (72) | |
| Lung cancer | 6PGD | Translation | Promote cell proliferation | (22) | |
| AML | Tnfrsf2 | Stability | Promote LSC development and AML initiation | (73) | |
| Bladder cancer | SETD7, KLF4 | Degradation | Promotes cell migration | (74) | |
| Prostate cancer | LHPP, NKX3–1 | Degradation | Promote cell proliferation and migration | (75) | |
| Melanoma | PD-1, CXCR4, SOX10 | Degradation | Inhibit cell proliferation and migration | (76) | |
| YTHDF3 | CRC | LncRNA GAS5 | Degradation | Promote CRC progression | (77) |
| YTHDF1/3 | Bladder cancer | ITGA6 | Translation | Promote cell proliferation and migration | (78) |
| YTHDC2 | CRC | HIF-1α,Twist1 | Translation | Promote cell metastasis | (79) |
HCC, hepatocellular carcinoma; CRC, colorectal cancer; MCC, Merkel cell carcinoma; AML, acute myeloid leukemia; EMT, epithelial mesenchymal transition; CSC, cancer stem cell; LSC, leukemic stem cell.