. 2021 Apr 13;11:662710. doi: 10.3389/fcimb.2021.662710

Table 2.

Effects of IgY on serum immunoglobulins and sIgA level in jejunum of mice challenged by ETEC K88.

Immunoglobulin	Control	ETEC challenge	Levels of anti-ETEC IgY(mg/mL)			Non-specific IgY	SEM	P value
Immunoglobulin	Control	ETEC challenge	32	16	8	Non-specific IgY	SEM	P value
IgG, μg/mL	312.29^b	401.28^a	333.56^b	350.20^b	340.34^b	394.71^a	9.46	< 0.01
IgM, μg/mL	48.50	52.27	48.36	50.43	47.10	47.00	3.27	0.86
IgA, ng/mL	460.33^c	543.04^a	485.42^bc	463.43^c	510.40^ab	539.71^a	9.47	< 0.01
sIgA, μg/mL	12.22^c	13.22^bc	14.54^ab	15.35^a	13.90^b	13.64^bc	0.31	< 0.01

^a-cValues with different superscripts within a row differ (P < 0.05), n=6. Mice in control group were not challenged with ETEC K88. Mice in ETEC group were challenged with ETEC K88 and treated with PBS. Mice in IgY groups were challenged with ETEC K88 and treated with 250 μL of high-, medium- or low-doses of anti-ETEC IgY or 250 μL of non-specific IgY.