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. 2021 Apr 13;10:596623. doi: 10.3389/fonc.2020.596623

Figure 4.

Figure 4

CircZFR modulates WNT5A expression through sponge miR-1270 and miR-545. (A) Prediction of putative miR-1270 and miR-545 binding site with WNT5A mRNA and the relative luciferase activity with or without WNT5A mutation. (**P < 0.01 vs. miR-NC, n = 3) (B) mRNA and protein expression when miR-1270/miR-545 are overexpressed in BCa cells. (**P < 0.01 vs. miR-NC, n = 4) (C) mRNA and protein expression in circZFR knockdown cells with or without treatment. (**P < 0.01 vs. sh-NC, ##P < 0.01 vs. sh-circZFR, n = 3) (D) WNT5A expression levels in BCa tissues (BC) and adjacent normal tissues (Normal). (**P < 0.01 vs. normal group, n = 60) (E) Pearson correlation analysis between the expression of WNT5A and miR-1270/miR-545, circZFR.