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Cellular uptake and intracellular localization of LPHM@DDI NPs. (A) Confocal microscopic images of 4T1 cells after 2 h of incubation with DDI, LM@DDI, PM@DDI, and LPHM@DDI NPs. Mean fluorescence intensities (MFIs) of DOX (B) and IR780 (C) in 4T1 cells after incubation with the above NPs. Flow cytometry analysis of Raw 264.7 cells after 1 h of incubation of DDI, LM@DDI, PM@DDI and LPHM@DDI NPs (D) and MFIs of intracellular DOX (E). ** represents P < 0.01 vs. control.
