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. 2021 Mar 13;24:646–657. doi: 10.1016/j.omtn.2021.03.009

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

HDAC1 binds KLF5 to suppress its transcription and induce the expression of IKBα in HUVECs

(A) Bioinformatics website STRING (https://string-db.org/cgi/network.pl?taskId=LIdtFKtm9mBY) predicted that HDAC1 targeting regulates KLF5. (B) The binding of HDAC1 and KLF5 in HUVECs treated with ox-LDL. (C) KLF5 and IKBα levels in HUVECs. (D) HDAC1 can inhibit IKBα through KLF5; ∗p < 0.05. Measured data are described as mean ± standard deviation. Unpaired t test was used to analyze data between two groups and ANOVA test to analyze data among multiple groups. All of the experiments were performed with technological triplicate.