Table 1.
Serum values, vital signs and scores at different time points
| Hospital admission day Disease day |
d1 | d2 | d3 | d4 | d5 | d6 | d7 | d8 | d9 | d10 | d18 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| d10 | d11 | d12 | d13 | d14 | d15 | d16 | d17 | d18 | d19 | d27 | ||||
| Risperidone | ||||||||||||||
| Dexamethasone | ||||||||||||||
| Baricitinib and remdesivir | ||||||||||||||
| Parameter | Range | Unit | ||||||||||||
| Oxygen flow | – |
L/min (L/min/FiO2) |
1 | 4 | 6 | HFNC (50/0.6) | HFNC (40/0.4) | HFNC (40/0.35) | HFNC (30/0.35) | 3 | 2 | 0 | – | 0 |
| O2 saturation | (95.0–99.0) | % | 98 | 95 | 93 | 98 | 94 | 98 | 100 | 99 | 99 | 98 | – | 98 |
| SARS-CoV‑2 PCR | – | – | Positive | – | – | – | – | – | – | Negative | – | – | – | – |
| – N-gene Ct-value | – | – | 33.94 | – | – | – | – | – | – | – | – | – | – | – |
| – RdRP gene Ct-value | – | – | 34.98 | – | – | – | – | – | – | – | – | – | – | – |
| – E-Gene Ct-value | – | – | 33.05 | – | – | – | – | – | – | – | – | – | – | – |
| C‑reactive protein | (< 0.5) | mg/L | 51.70 | 71.70 | 146.70 | 153.60 | 62.00 | 25.20 | 13.70 | 5.30 | 5.10 | – | – | – |
| Interleukin‑6 | (< 7) | pg/mL | 12 | 29 | 180 | 35 | 2 | 5 | 4 | 5 | 4 | – | – | – |
| Procalcitonin | (< 0.05) | ng/mL | 0.04 | 0.04 | 0.13 | 0.16 | 0.12 | 0.04 | 0.03 | 0.02 | 0.03 | – | – | – |
| Ferritin | (22–275) | ng/mL | 496 | 1653 | 1789 | 1910 | 1676 | 1096 | 1240 | 804 | 596 | – | – | – |
| D‑dimer | (< 0.50) | µg/mL | 0.60 | 0.23 | 0.89 | 1.07 | 1.05 | 1 | 0.97 | 1.01 | 1.06 | – | – | – |
| Lactate | (0.5–2.0) | Mmol/L | 1.10 | 1.21 | 1.32 | 0.80 | 1.10 | 0.90 | 0.80 | 0.60 | 0.60 | – | – | – |
| paO2 | (70–100) | mm Hg | 70 | 86 | 81 | 78 | 63 | 78 | 114 | 106 | 94 | – | – | – |
| paCO2 | (35–46) | mm Hg | 35 | 32 | 35 | 36 | 37 | 38 | 38 | 43 | 41 | – | – | – |
| Hemoglobin | (13.0–17.5) | g/dL | 14.80 | 13.40 | 13.80 | 13.80 | 120 | 11.70 | 11.30 | 11.90 | 12.40 | – | – | – |
| White blood cells | (4.00–10.00) | 10^9/L | 10.16 | 9.94 | 16.35 | 12.12 | 5.90 | 8.76 | 7.93 | 8.3 | 12.72 | – | – | – |
| Platelet count | (150–370) | 10^9/L | 203 | 208 | 274 | 310 | 289 | 324 | 311 | 361 | 419 | – | – | – |
| LDH | (< 250) | kU/L | 145 | 187 | 235 | 449 | 348 | 337 | 314 | 196 | 356 | – | – | – |
| AST | (5–34) | U/L | 32 | 44 | 32 | 27 | 25 | 31 | 31 | 26 | 47 | – | – | – |
| ALT | (0–55) | U/L | 78 | 64 | 46 | 35 | 35 | 46 | 57 | 71 | 144 | – | – | – |
| GGT | (0–66) | U/L | 88 | 165 | 170 | 139 | 107 | 103 | 97 | 69 | 104 | – | – | – |
| Alkaline phosphatase | (43–160) | U/L | 65 | 66 | 79 | 121 | 55 | 50 | 45 | 32 | 49 | – | – | – |
| Serum creatinine | (0.70–1.30) | mg/dL | 0.91 | 0.67 | 0.70 | 0.59 | 0.56 | 0.58 | 0.54 | 0.40 | 0.60 | – | – | – |
| Calcium | (2.10–2.58) | Mmol/L | 2.26 | 2.05 | 2.09 | 2.07 | 2.06 | 2.01 | 2.01 | 2.35 | 2.07 | – | – | – |
| Ionized calcium | (1.17–1.34) | Mmol/L | 1.21 | 1.19 | 1.18 | 1.21 | 1.21 | 1.23 | 1.19 | 1.24 | 1.22 | – | – | – |
| 25-OH vitamin D3 | (20.0–70.0) | ng/mL | – | – | – | 19.60 | – | – | – | – | – | 21.20 | – | – |
| CTX | (< 0.584) | ng/mL | – | – | – | 0.465 | – | – | – | – | – | 1.250 | – | – |
| P1NP | (15–59) | µg/L | – | – | – | 23.98 | – | – | – | – | – | 12.56 | – | – |
| iPTH | (15.0–65.0) | pg/mL | – | – | – | 13.8–0 | – | – | – | – | – | 23.70 | – | – |
| UPDRS III score | Max 56 | – | – | – | – | – | – | – | – | – | – | 49 | – | 15 |
SARS-CoV‑2 PCR Severe acute respiratory syndrome coronavirus 2 polymerase chain reaction, Ct value cycle threshold value, paO2 partial arterial pressure of oxygen, paCO2 partial arterial pressure of carbon dioxide, O2 oxygen, HFNC high-flow oxygen nasal cannula, LDH lactate dehydrogenase, AST aspartate transaminase, ALT alanine transaminase, GGT gamma glutamyl transferase, CTX carboxy-terminal collagen crosslinks, P1NP procollagen type 1 N‑terminal propeptide, iPTH intact parathyroid hormone, UPDRS unified Parkinson’s disease rating scale III, FiO2 N‑gene, E‑gene RdRP gene