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. 2021 Apr 13;9:665305. doi: 10.3389/fbioe.2021.665305

FIGURE 5.

FIGURE 5

The co-culture model of bacterial multispecies and HGFs. (A) CLSM images of HGFs seeded on different samples after 6 and 24 h of contamination by bacterial multispecies biofilms. The green and blue dyes marked the cytoskeleton and nuclei of HGFs, respectively. Scale bar = 100 μm. (B) Noted that cell coverage (%) on Ti-0.125G increased as compared to the control (*p < 0.05, **p < 0.01). (C) Schematic circuitry of the proposed mechanism to clarify the bactericidal ability of the Gr-reinforced sample. (1) and (3) The primary stages of a “race-for-the-surface” between bacterial multispecies biofilms and HGFs on Cp-Ti and Ti-0.125G, respectively. (2) and (4) The late stages of a “race-for-the-surface” between bacterial multispecies biofilms and HGFs on Cp-Ti and Ti-0.125G, respectively.