The potential response model to salinity stress in cotton during early developmental stage. When exposed to salinity stress, the resultant stress signal alters secondary messengers, such as calcium (Ca2+), ROS, and stress hormones (ABA and ET). Downstream MAPK cascades influence expression of TFs (e.g., AP2/ERF, MYB, NAC, WRKY, and bZIP) that regulate target gene expression. These target genes are involved in ROS generation and scavenging, leading to varying salinity-stress responses. CTR1, constitutive triple response 1; NDPK2, nucleoside diphosphate kinase 2; ACS, 1-aminocyclopropane-1-carboxylic acid synthase; NCED, 9-cis-epoxycarotenoid dioxygenase; SAMS, s-adenosylmethionine synthase; SnRK2, sucrose nonfermenting 1 (SNF1)-related protein kinase 2; ETR1, ethylene response 1; CYP707A, cytochrome p450 family 707A; ACO, 1-aminocyclopropane-1-carboxylate oxidase 1; ABF, ABRE-binding factor; PP2C, protein phosphatases 2C; PYL, pyrabactin resistance1/PYR1-likes; SAMDC, s-adenosylmethionine decarboxylase proenzyme; RbohA-D, respiratory burst oxidase homologs A-D; APX3, ascorbate peroxidase 3; PNC1, cationic peroxidase 1; CAT, catalase; POD, peroxidase.