Table 2. Diagnostic Performance, Sensitivity, and Specificity of CT Set and CT Plus PET/MRI Set in the Initial Workup Group.
| Reviewer 1 | Reviewer 2 | |||||
|---|---|---|---|---|---|---|
| CT | CT + PET/MRI | P | CT | CT + PET/MRI | P | |
| The likelihood of malignancy | ||||||
| Az | 0.95 (0.87–0.99) | 0.97 (0.89–1.00) | 0.716 | 0.96 (0.88–0.99) | 0.93 (0.83–0.98) | 0.297 |
| Sensitivity (%)* | 93.2 (55/59) | 94.9 (56/59) | 1.000 | 91.5 (54/59) | 93.2 (55/59) | 1.000 |
| Specificity (%)* | 83.3 (5/6) | 100.0 (6/6) | 1.000 | 100.0 (6/6) | 100.0 (6/6) | NA |
| Local resectability | ||||||
| Az | 0.95 (0.84–1.00) | 0.97 (0.86–1.00) | 0.191 | 0.88 (0.71–0.96) | 0.90 (0.76–0.97) | 0.563 |
| Sensitivity (%) | 90.6 (29/32) | 93.7 (30/32) | 1.000 | 81.2 (26/32) | 81.2 (26/32) | 1.000 |
| Specificity (%) | 87.5 (7/8) | 87.5 (7/8) | NA | 62.5 (5/8) | 75.0 (6/8) | 1.000 |
| Distant lymph node metastasis | ||||||
| Az | 0.73 (0.60–0.84) | 0.92 (0.82–0.98) | 0.004 | 0.81 (0.68–0.90) | 0.92 (0.81–0.97) | 0.023 |
| Sensitivity (%) | 50.0 (10/20) | 80.0 (16/20) | 0.070 | 60.6 (12/20) | 85.0 (17/20) | 0.125 |
| Specificity (%) | 92.3 (36/39) | 92.3 (36/39) | 1.000 | 84.6 (33/39) | 92.3 (36/39) | 0.375 |
| Hepatic metastasis | ||||||
| Az | 0.77 (0.64–0.87) | 0.91 (0.81–0.97) | 0.027 | 0.76 (0.64–0.86) | 0.92 (0.81–0.97) | 0.021 |
| Sensitivity (%) | 52.6 (10/19) | 84.2 (16/19) | 0.016 | 57.9 (11/19) | 89.5 (17/19) | 0.031 |
| Specificity (%) | 97.5 (39/40) | 97.5 (39/40) | NA | 100 (40/40) | 92.5 (37/40) | 0.250 |
| Peritoneal seeding | ||||||
| Az | 0.90 (0.80–0.96) | 0.92 (0.81–0.97) | 0.795 | 0.88 (0.77–0.95) | 0.92 (0.83–0.98) | 0.474 |
| Sensitivity (%) | 71.4 (5/7) | 85.7 (6/7) | 1.000 | 57.1 (4/7) | 71.4 (5/7) | 1.000 |
| Specificity (%) | 98.1 (51/52) | 98.1 (51/52) | NA | 100.0 (52/52) | 98.1 (51/52) | 1.000 |
| Other metastasis | ||||||
| Az | 0.56 (0.43–0.69) | 1.00 (0.94–1.00) | < 0.0001 | 0.51 (0.38–0.64) | 0.88 (0.76–0.95) | < 0.0001 |
| Sensitivity (%) | 12.5 (1/8) | 100.0 (8/8) | 0.016 | 0 (0/8) | 75.0 (6/8) | 0.031 |
| Specificity (%) | 100.0 (51/51) | 100.0 (51/51) | NA | 98.0 (50/51) | 100.0 (51/51) | 1.000 |
| Overall resectability | ||||||
| Az | 0.79 (0.66–0.88) | 0.92 (0.82–0.98) | 0.007 | 0.82 (0.70–0.91) | 0.94 (0.85–0.99) | 0.021 |
| Sensitivity (%) | 85.7 (24/28) | 89.3 (25/28) | 1.000 | 75.0 (21/28) | 85.7 (24/28) | 0.453 |
| Specificity (%) | 67.7 (21/31) | 90.3 (28/31) | 0.016 | 77.4 (24/31) | 96.8 (30/31) | 0.031 |
Data were calculated using the z-test. The numbers in parentheses are 95% confidence intervals. *Calculated using the McNemar test. Numbers in parentheses are numbers of patients. Az = area under the receiver operating characteristic curve, NA = not assessable