Table 3. The MTR_asym Values at 1, 2, 3, and 3.5 ppm Offset Frequencies and the Corresponding Results of the Statistical Comparisons between the Participants with and without Dementia for Each ROI.

ROI	Non-Dementia (Mean ± SD)	Dementia (Mean ± SD)	P
1 ppm
AC	-0.243 ± 0.508	0.095 ± 0.686	0.078
Hippocampus	0.232 ± 0.138	0.165 ± 0.178	0.186
Parahippo	0.245 ± 0.137	0.174 ± 0.175	0.153
Pons	0.322 ± 0.215	0.418 ± 0.238	0.179
Precuneus	0.250 ± 0.398	0.202 ± 0.374	0.696
Putamen	0.243 ± 0.139	0.306 ± 0.304	0.382
2 ppm
AC	0.543 ± 0.548	1.097 ± 0.939	0.024*
Hippocampus	0.887 ± 0.287	1.190 ± 0.658	0.057
Parahippo	0.991 ± 0.347	1.225 ± 0.494	0.084
Pons	0.892 ± 0.514	1.234 ± 0.652	0.068
Precuneus	0.935 ± 0.771	1.158 ± 0.825	0.377
Putamen	1.116 ± 0.308	1.190 ± 0.658	0.064
3 ppm
AC	0.290 ± 0.662	0.987 ± 1.269	0.030*
Hippocampus	0.748 ± 0.413	1.138 ± 0.624	0.022*
Parahippo	0.886 ± 0.401	1.163 ± 0.542	0.068
Pons	0.976 ± 0.651	1.172 ± 0.718	0.363
Precuneus	1.070 ± 0.752	1.201 ± 0.839	0.601
Putamen	0.903 ± 0.444	1.230 ± 0.554	0.042*
3.5 ppm
AC	-0.090 ± 0.678	0.954 ± 1.469	0.005*
Hippocampus	0.463 ± 0.374	0.875 ± 0.754	0.029*
Parahippo	0.635 ± 0.436	0.831 ± 0.712	0.288
Pons	0.812 ± 0.745	0.857 ± 0.863	0.861
Precuneus	0.904 ± 0.986	1.121 ± 0.866	0.463
Putamen	0.509 ± 0.465	0.985 ± 0.653	0.010*

The unit of this value is percent (%). Data show mean ± SD.

^*Statistical significant difference between the two groups. AC = anterior cingulate, MTR_asym = magnetization transfer ratio asymmetry, Parahippo = parahippocampal gyrus, ROI = region-of-interest