Table 5. Results of the ROC Curve Analysis to Evaluate the Added Values of CEST Indices with GMV for the Group Classifications.

ROI	AUC	P	Combined AUC	P
Amide
AC	0.505	0.96	0.95	< 0.001
Hippocampus	0.526	0.788	0.964	< 0.001
Parahippo	0.514	0.882	0.959	< 0.001
Pons	0.577	0.405	0.770	0.006
Precuneus	0.567	0.472	0.888	< 0.001
Putamen	0.522	0.821	0.778	0.002
Amine
AC	0.707	0.018	0.940	< 0.001
Hippocampus	0.700	0.028	0.955	< 0.001
Parahippo	0.718	0.019	0.959	< 0.001
Pons	0.737	0.004	0.801	0.001
Precuneus	0.544	0.636	0.888	< 0.001
Putamen	0.627	0.183	0.825	< 0.001
OH
AC	0.717	0.010	0.967	< 0.001
Hippocampus	0.679	0.049	0.955	< 0.001
Parahippo	0.648	0.121	0.959	< 0.001
Pons	0.541	0.668	0.744	0.003
Precuneus	0.525	0.796	0.876	< 0.001
Putamen	0.586	0.368	0.811	< 0.001
Water DWS
AC	0.756	< 0.001	0.976	< 0.001
Hippocampus	0.696	0.023	0.967	< 0.001
Parahippo	0.684	0.032	0.969	< 0.001
Pons	0.556	0.540	0.730	0.005
Precuneus	0.533	0.717	0.885	< 0.001
Putamen	0.645	0.113	0.833	< 0.001
MT
AC	0.522	0.818	0.964	< 0.001
Hippocampus	0.678	0.036	0.959	< 0.001
Parahippo	0.678	0.035	0.962	< 0.001
Pons	0.525	0.787	0.737	0.003
Precuneus	0.507	0.939	0.880	< 0.001
	0.638	0.122	0.842	< 0.001
NOE
AC	0.575	0.409	0.945	< 0.001
Hippocampus	0.681	0.035	0.952	< 0.001
Parahippo	0.669	0.056	0.955	< 0.001
Pons	0.563	0.488	0.739	0.003
Precuneus	0.537	0.692	0.892	< 0.001
Putamen	0.657	0.074	0.830	< 0.001
Base
AC	0.627	0.161	0.967	< 0.001
Hippocampus	0.697	0.018	0.957	< 0.001
Parahippo	0.695	0.019	0.976	< 0.001
Pons	0.547	0.614	0.737	0.003
Precuneus	0.554	0.561	0.892	< 0.001
Putamen	0.689	0.026	0.837	< 0.001
MTRasym 1 ppm
AC	0.632	0.142	0.967	< 0.001
Hippocampus	0.617	0.2037	0.959	< 0.001
Parahippo	0.629	0.154	0.959	< 0.001
Pons	0.644	0.1142	0.794	< 0.001
Precuneus	0.536	0.699	0.876	< 0.001
Putamen	0.524	0.8052	0.799	< 0.001
MTRasym 2 ppm
AC	0.682	0.034	0.981	< 0.001
Hippocampus	0.656	0.096	0.955	< 0.001
Parahippo	0.612	0.22	0.962	< 0.001
Pons	0.642	0.106	0.780	< 0.001
Precuneus	0.62	0.194	0.88	< 0.001
Putamen	0.683	0.045	0.852	< 0.001
MTRasym 3 ppm
AC	0.667	0.055	0.957	< 0.001
Hippocampus	0.708	0.015	0.957	< 0.001
Parahippo	0.658	0.073	0.969	< 0.001
Pons	0.593	0.327	0.792	0.001
Precuneus	0.586	0.355	0.880	< 0.001
Putamen	0.677	0.04	0.821	< 0.001
MTRasym 3.5 ppm
AC	0.76	< 0.001	0.962	< 0.001
Hippocampus	0.672	0.059	0.959	< 0.001
Parahippo	0.586	0.372	0.964	< 0.001
Pons	0.557	0.547	0.734	0.004
Precuneus	0.605	0.25	0.888	< 0.001
Putamen	0.703	0.014	0.825	< 0.001

Combined AUC, AUC value by both CEST index and GMV. AC = anterior cingulate, AUC = area under the ROC curve, CEST = chemical exchange saturation transfer, DWS = direct water saturation, GMV = gray matter volume, MT = magnetization transfer, MTR_asym = magnetization transfer ratio asymmetry, NOE = nuclear overhauser effect, OH = hydroxyl, Parahippo = parahippocampal gyrus, ROC = receiver operating characteristic, ROI = region-of-interest