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. 2021 Apr 22;15:1653–1666. doi: 10.2147/DDDT.S297500

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© 2021 Liu et al.

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Potential interaction loop among mitochondrial function, the Ca²⁺/CaMK signaling pathway, and the ROCK pathway. FDCA inhibited hypoxia-induced PASMC proliferation, migration, and contraction by restoring mitochondrial function, reducing [Ca²⁺]_i, and inhibiting the Ca²⁺/CaMK activity and the ROCK pathway activity.

Abbreviations: PDK, pyruvate dehydrogenase kinase; Ca2+/CaMKs, calcium/calmodulin-dependent kinases; MLCK, Ca2+/calmodulin-dependent myosin light chain kinase; MYPT1, myosin phosphatase-targeting subunit 1; MLCP, myosin light chain phosphorylase.