Table 2. Annual changes in initial severity, diagnostic evaluation, site of infection, antibiotic treatment, clinical course, and outcomes of adult SAB.

Characteristics		No. (%) of patients (n = 1,782)	Annual change (%)	P value
Initial severity of SAB
	Pitt bacteremia median score (IQR)	1 (0–2)	−0.039	0.007
	APACHE score (day of bacteremia), median (IQR)	15 (11–20)	−0.163	0.003
Diagnostic evaluation for site of infection
	Transthoracic echocardiogram	1,465 (82.2)	1.222	0.007
	Transesophageal echocardiogram	263 (14.8)	0.053	0.845
	Spine MRI	264 (14.8)	2.282	0.004
	Ophthalmologic evaluation	1,179 (66.2)	4.774	< 0.001
Site of infection
	Central venous catheter infection	475 (26.7)	−2.440	< 0.001
	Pneumonia	250 (14.0)	0.604	0.120
	Skin-soft tissue infection	237 (13.3)	−0.410	0.118
	Bone-joint infection	227 (12.7)	0.309	0.386
	Surgical site infection	100 (5.6)	−0.111	0.629
	Infective endocarditis	90 (5.1)	0.020	0.917
	Central nervous system infection	58 (3.3)	0.110	0.566
	Urinary tract infection	44 (2.5)	−0.020	0.898
	Primary bacteremia	280 (15.7)	0.239	0.534
	Any metastatic infection	319 (17.9)	−0.352	0.517
Courses and outcomes of SAB
	Persistent bacteremia I (SAB duration ≥ 7 days)	245/1,760 (13.9)	−0.654	0.120
	Persistent bacteremia II (SAB duration ≥ 6 days)	304/1,760 (17.3)	−1.016	0.021
	Duration of SAB, mean day (SD) (n = 1,760)	3.53 (5.89)	−0.128	0.051
	30-day mortality	283 (15.9)	−0.024	0.227
	60-day mortality	402 (22.6)	−0.018	0.388
	90-day mortality	488 (27.4)	−0.042	0.137
	Recurrence within 3 mon	90 (5.1)	−0.446	0.167

SAB = Staphylococcus aureus bacteremia, IQR = interquartile range, APACHE = Acute Physiology and Chronic Health Evaluation, MRI = magnetic resonance imaging, SD = standard deviation.