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. 2021 Apr 27;22:127. doi: 10.1186/s12931-021-01686-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — More severe airflow obstruction is associated with lower plasma and serum sRAGE in multiple cohorts and with different assay platforms for sRAGE. sRAGE is shown on the log-scale y-axis. Shown are the QBR assays for COPDGene (n = 1437) (a) and ECLIPSE (n = 2342) (b), DuoSet for sRAGE assay for SCCOR (n = 399) (c), and RBM assay for R&D SPIROMICS (n = 1620) (d). Median, 25th percentile, 75th percentile, and whiskers (the minimum of 1.5 times interquartile range (IQR) or highest/lowest value) are shown in the box plots. e Forest plot of sRAGE effect size estimates for baseline FEV₁ for each cohort (squares) as well as a weighted estimate of the meta-analysis (diamond). The shaded represents the interquartile range and the whiskers represent the 95% confidence interval. f Forest plot of sRAGE effect size estimates with FEV₁ decline for each cohort (squares) as well as a weighted estimate of the meta-analysis (diamond). The shaded represents the interquartile range and the whiskers represent the 95% confidence interval