TABLE 1.

Intrathymic expression of non-neuronal neurotransmitters and their corresponding receptors.

Non-neuronal			Cell types expressing the
neurotransmitter	Cell type producer		corresponding receptors		References
	TEC	Thymocytes	TEC	Thymocytes
Acetylcholine	+	+	α2, α3, α5, α7, β4, ε*	α3, α5, α7, β2, β4*	Rinner et al., 1999; Kawashima and Fujii, 2004; Panneck et al., 2014
Dopamine	+	Lowlevels detected	ND	D1, D2, D3, D4, D5	Pilipović et al., 2008; Mignini et al., 2009, 2013; Lifantseva et al., 2016
Norepinephrine	+	+	α1, β1, β2**	α1, β2**	Marchetti et al., 1994; Leposavić et al., 2008; Pešić et al., 2009; Roggero et al., 2011
Serotonin	ND	+	ND	5-HT1B, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT6, 5-HT7	Stefulj et al., 2000; Lifantseva et al., 2017
Vasoactive intestinal peptide	+	ND	ND	VIPR, VIP1R	Delgado et al., 1996a,b; Silva et al., 2006
Neuropeptide Y	+	ND	ND	Y1,Y2,Y3 (possibly)	Medina et al., 2000; Silva et al., 2006
Calcitonin gene related peptide	+	ND	ND	CGPR1	Kurz et al., 1995; Silva et al., 2006
Substance P	+	+	ND	NK-1R	Santoni et al., 2002; Silva et al., 2006
Oxytocin	+	ND	ND	OTR	Robert et al., 1991; Hansenne et al., 2005; Savino et al., 2016
Arg-Vasopressin	+	ND	ND	V1bR	Robert et al., 1991; Hansenne et al., 2005; Savino et al., 2016
Somatostatin	+	ND	sst1, sst2A	sst2A, sst3, sst4	Ferone et al., 2002; Silva et al., 2006

ND, Not determined; TEC, thymic epithelial cells; * α 2-7, β2-4, and ε, Nicotinic receptor subunits; D1-5, Doparminergic receptor; ** α1, and β1-2, Norepinephrine receptor; 5-TH1-7, Serotoninergic receptors; VIPR, Vasoactive Intestinal Peptide Receptor; Y, neuropeptide receptor; CGPR, Calcitonin Gene Related Peptide Receptor, NK-1R, Neurokinin 1-Receptor, OTR, Oxytocin Receptor, V1bR, Vasopressin V1b Receptor, sst 2-4, Somatostatin Receptor.