TABLE 1.

Biometric and echocardiographic parameters of the experimental mice.

	WT			TLR2KO
	Ctrl N = 7	DOX N = 7	DOX + LCZ N = 7	Ctrl N = 7	DOX N = 7
EF%	80.14 ± 1.05	75.74 ± 1.08***	78.25 ± 1.17###	81.08 ± 1.75	79.18 ± 2.01###
FS%	40.26 ± 2.49	35.11 ± 2.11***	38.36 ± 2.47###	39.27 ± 1.81	38.75 ± 1.41###
LVIDd, mm	2.11 ± 0.28	2.35 ± 0.56**	2.18 ± 0.14##	2.10 ± 0.58	2.15 ± 0.78##
IVSD, mm	0.98 ± 0.11	0.95 ± 0.14*	0.99 ± 0.22#	0.98 ± 0.07	0.99 ± 0.1#
PWd, mm	0.70 ± 0.03	0.67 ± 0.04**	0.71 ± 0.13#	0.71 ± 0.21	0.71 ± 0.35#
E wave, m/s	0.68 ± 0.05	0.70 ± 0.07**	0.69 ± 0.07#	0.67 ± 0.08	0.69 ± 0.11#
Tei Index	0.82 ± 0.04	0.80 ± 0.10**	0.82 ± 0.12#	0.81 ± 0.11	0.82 ± 0.25#
IRT, ms	15.33 ± 1.14	17.28 ± 1.58*	14.56 ± 1.97#	14.23 ± 1.46	14.28 ± 1.41#

Transthoracic echocardiography was performed on mice at the end of the animal study. EF, ejection fraction%, FS, fractional shortening%; LVIDd, diastole left ventricle internal dimension; PWd, diastole posterior wall thickness; IVSd, diastole interventricular septal thickness; E wave; IRT, isovolumic relaxation time; Tei index; Data are presented as the mean ± SEM, n = 7. *P < 0.05 compared to ctrl; **P < 0.01 compared to ctrl; ***P < 0.001 compared to ctrl; #P < 0.05 compared to Ang II; ##P < 0.01 compared to Ang II; ###P < 0.001 compared to Ang II; ns = not significant.