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. 2021 Apr 13;12:657698. doi: 10.3389/fendo.2021.657698

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Copyright © 2021 Calissendorff, Bjellerup-Calissendorff, Bränström, Juhlin and Falhammar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Examples of routine histological and immunohistochemical features of a metastatic pan-NETs WHO grade 2 (Pan-NET G2) from the Karolinska cohort. Metastatic Pan-NETs tissue is evident to the right, while the left section of each image depicts liver tissue. Note the well-differentiated tumoral growth pattern on routine H&E staining. Tumor cells were diffusely positive for markers of neuroendocrine differentiation (CGA, SYP, ISL1) and displayed stainings indicating a pancreatic origin (ISL1, PDX1). The tumor grade was determined to G2, which in this manuscript would translate to the hypothetical G2a category. This patient had been previously diagnosed with a primary pan-NET (data not shown). All photomicrographs were magnified x100.