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. 2021 Apr 13;12:625593. doi: 10.3389/fphar.2021.625593

FIGURE 4.

FIGURE 4

Association of MGA Mutation with tumor mutational burden, neoantigen load and DNA damage repair (DDR) deficiency in patients with non-squamous NSCLC (A) Comparison of tumor mutational burden between MGA-mutated and wild-type subgroups from ICI-treated NSCLC and the TCGA-LUAD cohorts (B) Comparison of neoantigen load between MGA-mutated and wild-type subgroups in the TCGA-LUAD cohort (C) Comparison of mutation amounts of DDR pathway genes between MGA-mutated and wild-type subgroups in the TCGA-LUAD cohort. Mann-Whitney U test was used to test the differences. ns: not significant; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. BER, base excision repair; DR, direct damage reversal repair; FA, Fanconi anemia; HDR, homology-dependent recombination; MMR, mismatch repair; NER, nucleotide excision repair; NHEJ, non-homologous end joining; NP, nucleotide pool maintenance; TLS, translesion DNA synthesis.