TABLE 1.
Univariate and multivariable Cox regression analysis of progression-free survival in discovery cohort.
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Age (≥65 vs. <65 years) | 1.15 | 0.84 to 1.54 | 0.37 | — | — | — |
| Gender (male vs. female) | 1.13 | 0.84 to 1.53 | 0.43 | — | — | — |
| Smoking (ever vs. never) | 0.79 | 0.54 to 1.15 | 0.22 | — | — | — |
| TMB (high vs. low) | 0.87 | 0.64 to 1.18 | 0.37 | — | — | — |
| PD-L1 (≥1%vs. 0%) | 0.53 | 0.34 to 0.83 | 0.006 | 0.63 | 0.40 to 1.00 | 0.049 |
| Treatment (combination vs. monotherapy) | 0.69 | 0.49 to 0.96 | 0.026 | 0.57 | 0.36 to 0.90 | 0.016 |
| MGA (mutated vs. wild type) | 0.41 | 0.23 to 0.73 | 0.003 | 0.42 | 0.19 to 0.95 | 0.037 |
CI, confidence interval; HR, hazard ratio.