Table 2. Association Between Preeclampsia and Risk of Stroke Among Women in the Framingham Heart Study.
| Variable | Participants, No. (%) (N = 1435) | Person-years | Logistic model unadjusted | Logistic model adjusted for baseline factorsa | MSM model adjusted for time-varying factors from baseline to final visitb | |||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | RR (95% CI) | P value | |||
| History of preeclampsia | ||||||||
| No | 1266 (88.2) | 36 076 | 1 [Reference] | .53 | 1 [Reference] | .31 | 1 [Reference] | .02 |
| Yes | 169 (11.8) | 5346 | 1.14 (0.75-1.74) | 1.27 (0.80-2.00) | 3.79 (1.24-11.60) | |||
Abbreviations: MSM, marginal structural model; OR, odds ratio; RR, relative risk.
Adjusted for educational level (less than high school, high school graduate with some college, other post–high school educational degree [eg, business school, nursing school, and music or art school], and college graduate or higher) and baseline characteristics at enrollment in the Framingham Heart Study, including age (continuous), weight (continuous), total cholesterol level (continuous), blood glucose level (continuous), systolic blood pressure (continuous), diastolic blood pressure (continuous), receipt of treatment for hypertension (yes or no), receipt of treatment for hyperlipidemia (yes or no), and current smoking status (yes or no).
Adjusted for educational level, baseline characteristics, and potential mediating factors, including age (continuous) and weight (continuous) at follow-up visit, total cholesterol level (continuous), blood glucose level (continuous), systolic blood pressure (continuous), diastolic blood pressure (continuous), receipt of treatment for hypertension (yes or no), receipt of treatment for hyperlipidemia (yes or no), and current smoking status (yes or no).