Table 5.
Coefficient estimates, 95% confidence intervals, and P values from 2-level linear mixed models on the 3 study sites for exploring associations between sleep featuresa and the PHQ-8 score.
| Features | KCLb | CIBERc | VUmcd | ||||||||
|
|
Coeff.e | 95% CI | P value | Coeff. | 95% CI | P value | Coeff. | 95% CI | P value | ||
| Av_tst | 0.013 | 0.005, 0.020 | .001 | 0.016 | –0.001, 0.033 | .06 | 0.011 | 0, 0.022 | .049 | ||
| Av_time_bed | 0.016 | 0.008, 0.024 | <.001 | 0.021 | 0.002, 0.040 | .03 | 0.013 | 0.001, 0.025 | .04 | ||
| Deep_pct | –0.005 | –0.028, 0.018 | .69 | 0.024 | –0.022, 0.071 | .31 | –0.037 | –0.074, 0.001 | .06 | ||
| Light_pct | –0.046 | –0.087, –0.006 | .03 | –0.081 | –0.155, –0.007 | .03 | 0.019 | –0.043, 0.082 | .55 | ||
| REM_pct | 0.013 | –0.018, 0.043 | .43 | 0.015 | –0.042, 0.071 | .62 | –0.007 | –0.055, 0.041 | .77 | ||
| NREM_pct | –0.049 | –0.080, –0.018 | .002 | –0.060 | –0.116, –0.005 | .04 | –0.016 | –0.062, 0.030 | .50 | ||
| Awake_pct | 0.037 | 0.020, 0.054 | <.001 | 0.043 | 0.015, 0.071 | .003 | 0.022 | –0.003, 0.047 | .09 | ||
| Av_onset | 0.010 | 0.000, 0.020 | .047 | 0.004 | –0.018, 0.025 | .74 | –0.005 | –0.021, 0.010 | .52 | ||
| Av_offset | 0.029 | 0.018, 0.039 | <.001 | 0.024 | 0.004, 0.043 | .02 | 0.012 | –0.004, 0.029 | .14 | ||
| REM_L | 0.019 | –0.049, 0.088 | .58 | 0.106 | –0.026, 0.237 | .12 | –0.126 | –0.231, –0.020 | .02 | ||
| Std_tst | 0.008 | 0.003, 0.013 | .001 | 0.009 | 0, 0.019 | .06 | 0.002 | –0.006, 0.010 | .62 | ||
| Std_onset | 0.007 | –0.002, 0.016 | .14 | 0.019 | –0.001, 0.039 | .06 | 0.001 | –0.011, 0.013 | .93 | ||
| Std_offset | 0.009 | 0.001, 0.017 | .03 | 0.019 | 0.002, 0.036 | .03 | 0.003 | –0.008, 0.015 | .56 | ||
| Efficiency | –0.025 | –0.041, –0.008 | .004 | –0.043 | –0.071, –0.016 | .002 | –0.012 | –0.037, 0.013 | .34 | ||
| Awake_5 | 0.014 | 0.006, 0.022 | <.001 | 0.022 | 0.009, 0.035 | .001 | 0.016 | 0.005, 0.027 | .01 | ||
| WKD_diff | 0.211 | 0.084, 0.339 | .001 | 0.071 | –0.126, 0.268 | .48 | 0.077 | –0.144, 0.299 | .49 | ||
| M_insomnia | 0.472 | 0.259, 0.685 | <.001 | 0.381 | 0.028, 0.734 | .04 | –0.048 | –0.385, 0.289 | .78 | ||
| Dur_10 | 0.331 | 0.191, 0.472 | <.001 | 0.340 | 0.052, 0.627 | .02 | 0.181 | –0.051, 0.413 | .13 | ||
aDefinitions of sleep features in this table are shown in Table 1.
bKCL: King’s College London.
cCIBER: Centro de Investigación Biomédican en Red.
dVUmc: Vrije Universiteit Medisch Centrum.
eSlope coefficient estimates for all sleep features.