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. 2021 Jan 28;9(2):e1588. doi: 10.1002/mgg3.1588

FIGURE 1.

FIGURE 1

Subcellular localization of WT, F337C, and Q412P hClC‐1 channels. A, Schematic structure of a hClC‐1 channel subunit. The F337C mutation is located in the extracellular loop between I and J transmembrane domains. CBS is the cystathionine β‐synthase domain where ATP binds ClC‐1 and inhibits the common gating. B, Visualization of YFP‐tagged WT, F337C, or Q412P hClC‐1 channels in transfected HEK293 cells (scale bar: 5 µm). Note the clear membrane localization of WT and F337C channels, but not Q412P channels.