Table 2.

Morphological interpretation of the slopes in the Minkowsky functionals with respect to vascular networks

Metric	Slope	Sign	Morphologic interpretation
Area	Flat	+	Many branches, small intervascular spaces, tortuous vessels
	Steep		Few branches, large intervascular spaces, straight vessels
Boundary	Flat	−	Simple structure, few branches
	Steep		Complex structure, many branches
Spaces	Flat	+	Round lacunas, large variation in lacuna size
	Steep		Elongated lacunas, lacunas of similar size
	Flat	−	Sparse tree, few blind ends located far away from other vessels
	Steep		Dense tree, many blind ends close to other vessels