Table 3.

Odds ratios and 95% confidence intervals for each condition improving or resolving at 2-years post-baseline comparing those who reduce drinking (AUDIT<8) at 1-year with those who do not reduce drinking (AUDIT≥8) at 1-year, under different assumptions about the causal structure of the data

Condition improves	Analysis	Odds ratios (95% CIs)
Current moderate or severe pain	Figure 1a*	1.49 (0.91, 2.42)
Interference symptoms	Figure 1b**	1.77 (1.11, 2.84)
	Figure 1c***	1.48 (0.91, 2.42)
Current smoking	Figure 1a*	1.57 (0.93, 2.63)
	Figure 1b**	1.66 (1.00, 2.75)
	Figure 1c***	1.21 (0.72, 2.03)
Current depressive symptoms	Figure 1a*	1.11 (0.64, 1.92)
	Figure 1b**	1.21 (0.70, 2.06)
	Figure 1c***	0.98 (0.56, 1.72)
Current anxiety symptoms	Figure 1a*	1.33 (0.80, 2.22)
	Figure 1b**	1.28 (0.78, 2.11)
	Figure 1c***	1.23 (0.73, 2.07)
Past year cannabis use	Figure 1a*	1.65 (0.92, 2.95)
	Figure 1b**	1.85 (1.05, 3.25)
	Figure 1c***	1.66 (0.92, 3.01)
Past year cocaine	Figure 1a*	1.83 (1.03, 3.27)
	Figure 1b**	2.27 (1.31, 3.94)
	Figure 1c***	1.69 (0.94, 3.05)

^*Primary weighted analysis reported in Table 2. Adjusted for HIV status, race, education, income, baseline conditions (AUDIT score, depressive symptoms, anxiety symptoms, moderate or severe pain interference symptoms, current smoking, and past-year cannabis, cocaine, other stimulant, and illicit opioid use), and some time-varying covariates measured at 1-year (past-year cannabis, cocaine, other stimulant, and illicit opioid use).

^**All time-varying covariates measured at 1-year (past-year cannabis, cocaine, other stimulant, and illicit opioid use, depressive symptoms, anxiety, symptoms, smoking, and moderate or severe pain interference symptoms) excluded from the model for the weights.

^***All time-varying covariates measured at 1-year included in the model for the weights.